Synthesis, molecular docking and cholinesterase inhibitory activity of hydroxylated 2-phenylbenzofuran derivatives.
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DOI: 10.1016/j.bioorg.2018.11.043
Abstract: We have designed, synthesized and evaluated a series of hydroxylated 2-phenylbenzofuran derivatives as potential cholinesterase inhibitors. Starting from a series of 2-phenylbenzofurans previously published, in this paper we present a complete synthesis and the influence… read more here.
Keywords: phenylbenzofuran derivatives; hydroxylated phenylbenzofuran; inhibitory activity; activity ... See more keywords
Unexpected one-step synthesis of 3-benzoyl-2-phenylbenzofurans under Wittig conditions
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DOI: 10.1016/j.tetlet.2018.03.048
Abstract: Abstract The reaction of 2-hydroxybenzyltriphenylphosphonium bromide with substituted benzoyl chlorides under Wittig conditions, led to 2-phenylbenzofuran derivatives 4a–p and the unexpected formation of 3-benzoyl-2-phenylbenzofuran derivatives 5a–p. Benzoyl chlorides possessing electron-withdrawing groups afforded 3-benzoyl-2-phenylbenzofuran derivatives in… read more here.
Keywords: unexpected one; phenylbenzofuran derivatives; wittig conditions; benzoyl phenylbenzofuran ... See more keywords