Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1064-8
Abstract: Hyperoxaluria is characterized by an increased excretion of urinary oxalate which is caused by inherited disorders or high oxalate intake leading to renal stone ailment. Until date, reactive oxygen species and inflammation has been convicted… read more here.
Keywords: amelioration hyperoxaluria; stress; phenylbutyric acid; kidney ... See more keywords
Equilibrium of liquid-liquid extraction of 2-phenylbutyric acid enantiomers: Experiment and model
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2017.09.002
Abstract: Abstract The utilization of liquid–liquid extraction for the separation of 2-phenylbutyric acid (2-PBA) enantiomers was proposed. Factors affecting the extract process were investigated, including organic solvents, β-cyclodextrin derivatives, cyclodextrin concentration, pH and temperature. A model… read more here.
Keywords: liquid extraction; liquid liquid; phenylbutyric acid; liquid ... See more keywords
Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.04.002
Abstract: In the past two decades, significant advances have been made in the etiology of lipid disorders. Concomitantly, the discovery of liporegulatory functions of certain short-chain fatty acids has generated interest in their clinical applications. In… read more here.
Keywords: mechanisms therapeutic; phenylbutyric acid; butyric acid; molecular mechanisms ... See more keywords
Modeling and optimization of lipase-catalyzed hydrolysis for production of (S)-2-phenylbutyric acid enhanced by hydroxyethyl-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2019 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2019.05.011
Abstract: Abstract An efficient reactive system was established to produce (S)-2-phenylbutyric acid (2-PBA) through the enzymatic enantioselective hydrolysis of 2-phenylbutyrate ester (2-PBAE) in aqueous medium. Lipase CALA from Canadian antarctica and hexyl 2-phenylbutyrate (2-PBAHE) were identified… read more here.
Keywords: phenylbutyric acid; hydrolysis; cyclodextrin; lipase ... See more keywords
A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00640
Abstract: Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer effects. However, the low membrane permeability and poor cellular uptake limit its access to… read more here.
Keywords: anticancer activities; mitochondria targeted; acid prodrug; targeted phenylbutyric ... See more keywords
Short-chain Fatty Acids, 4-phenylbutyric Acid and R-α-lipoic Acid, Downregulate mTORC1-dependent Intestinal Fat Absorption (P08-115-19)
Sign Up to like & getrecommendations! Published in 2019 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzz044.p08-115-19
Abstract: Knowing that (i) high-fat diets upregulate inflammatory biomarkers in the small intestine and activate the mechanistic target of rapamycin complex 1 (mTORC1, a conserved protein kinase) and (ii) mTORC1 drives hepatic VLDL secretion, we investigated… read more here.
Keywords: mtorc1; short chain; phenylbutyric acid; fat absorption ... See more keywords
Erratum: Synergetic Effect of 4-Phenylbutyric Acid in Combination With Cyclosporine A on Cardiovascular Function in Sepsis Rats via Inhibition of Endoplasmic Reticulum Stress and Mitochondrial Permeability Transition Pore Opening
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.845186
Abstract: [This corrects the article DOI: 10.3389/fphar.2021.770558.]. read more here.
Keywords: phenylbutyric acid; acid combination; combination cyclosporine; effect phenylbutyric ... See more keywords
The effects of 4-Phenylbutyric acid on ER stress during mouse tooth development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1079355
Abstract: Introduction: During tooth development, proper protein folding and trafficking are significant processes as newly synthesized proteins proceed to form designated tissues. Endoplasmic reticulum (ER) stress occurs inevitably in tooth development as unfolded and misfolded proteins… read more here.
Keywords: effects phenylbutyric; development; tooth development; acid stress ... See more keywords
Andrographolide and 4-Phenylbutyric Acid Administration Increase the Expression of Antimicrobial Peptides Beta-Defensin-1 and Cathelicidin and Reduce Mortality in Murine Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11111629
Abstract: Antibiotic resistance is a global threat and requires the search for new treatment strategies. Natural antimicrobial peptides (AMPs) have pronounced antibacterial, antiviral, antifungal, and antitumor activity. AMPs’ clinical use is complicated by the high synthesis… read more here.
Keywords: mortality murine; antimicrobial peptides; beta defensin; expression ... See more keywords
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169403
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons. Mutations in the superoxide dismutase (SOD1) gene, causing protein misfolding and aggregation, were suggested as the pathogenic mechanisms involved… read more here.
Keywords: acid pba; aggregation; effect; disease ... See more keywords
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020298
Abstract: In recent years, 4-phenylbutyric acid (4-PBA), an FDA-approved drug, has increasingly been used as a nonspecific chemical chaperone in vitro and in vitro, but its pharmacodynamics is still not clear. In this context, we developed… read more here.
Keywords: acid pba; cell; chemical chaperone; acid ... See more keywords