Phenol‐benzoxazolone bioisosteres of GluN2B‐NMDA receptor antagonists: Unexpected rearrangement during reductive alkylation with phenylcyclohexanone
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DOI: 10.1002/ardp.202200225
Abstract: Negative allosteric modulators of N‐methyl‐ d‐aspartate receptors containing the GluN2B subunit represent promising drug candidates for the treatment of various neurological disorders including stroke, epilepsy, and Parkinson's disease. To increase the bioavailability and GluN2B affinity,… read more here.
Keywords: benzoxazolone bioisosteres; phenol benzoxazolone; phenol; glun2b nmda ... See more keywords