Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed-Dose Combination Tablets in Healthy Chinese Volunteers.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1625
Abstract: This single-center, randomized, open-label bioequivalence program compared two fixed-dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three-period, partially replicated… read more here.
Keywords: healthy chinese; dose combination; phenylephrine; fixed dose ... See more keywords
Phenylephrine infusion impact on surgical site infections after lower extremity bypass surgery
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2017.05.130
Abstract: Objective Lower extremity bypass (LEB) operations have high rates of surgical site infections (SSI). Phenylephrine is a commonly used vasoconstrictor which may reduce skin blood flow and increase the likelihood of SSI in these patients.… read more here.
Keywords: lower extremity; surgery; phenylephrine infusion; phenylephrine ... See more keywords
An open‐label, randomized, four‐treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.04.008
Abstract: ABSTRACT Phenylephrine hydrochloride (HCl) is a decongestant available in over‐the‐counter (OTC) medicines. Previously marketed prescription products contained phenylephrine tannate, an extended‐release salt, which allowed dosing every 8–12 h. Given the regulatory history that cold medicines… read more here.
Keywords: salt; acetaminophen; crossover study; hcl ... See more keywords
A Random-allocation Graded Dose-Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001880
Abstract: BACKGROUND Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However,… read more here.
Keywords: dose response; response; spinal anesthesia; cesarean delivery ... See more keywords
A randomised controlled trial of phenylephrine and noradrenaline boluses for treatment of postspinal hypotension during elective caesarean section
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DOI: 10.1111/anae.14675
Abstract: Phenylephrine is currently the vasopressor of choice during elective caesarean section, but it can cause reflex bradycardia. Noradrenaline, a potent α‐agonist and weak β‐agonist, may be associated with a lower incidence of bradycardia. However, comparative… read more here.
Keywords: postspinal hypotension; elective caesarean; phenylephrine noradrenaline; phenylephrine ... See more keywords
Does Switching Norepinephrine to Phenylephrine in Septic Shock Complicated by Atrial Fibrillation With Rapid Ventricular Response Improve Time to Rate Control?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Intensive Care Medicine"
DOI: 10.1177/0885066619896292
Abstract: Background: Atrial fibrillation (AF) frequently develops during critical illness. In septic shock complicated by rapid AF, the use of phenylephrine may be advantageous secondary to its β-1 sparing properties. However, evidence supporting this strategy is… read more here.
Keywords: phenylephrine; septic shock; rate; rate control ... See more keywords
Fluid vs. Phenylephrine: Compartment Syndrome in the Hand Following Massive Volume Resuscitation
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DOI: 10.1177/1558944720966738
Abstract: We thank the authors for the report on compartment syndrome in the hand of a patient following phenylephrine infusion.1 There are several aspects of the case that we believe require careful consideration before concluding that… read more here.
Keywords: compartment syndrome; fluid; hand; resuscitation ... See more keywords
Application of Racemization Process to Dynamic Resolution of (RS)-Phenylephrine to (R)-Phenylephrine β-D-Glucoside by Nicotiana tabacum Glucosyltransferase
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DOI: 10.1177/1934578x1801301113
Abstract: Enzymatic glucosylation of racemic phenylephrine by glucosyltransferase from Nicotiana tabacum gave (R)-phenylephrine glucoside and recovered (S)-phenylephrine. [RuCl2(p-cymene)]2 complex associated with simple hemisalen ligands or zeolite were able to racemize (S)-phenylephrine. The [RuCl2(p-cymene)]2/Ligand/TEMPO or zeolite racemization… read more here.
Keywords: racemization; glucosyltransferase; nicotiana tabacum; phenylephrine ... See more keywords
Cerebral oxygenation and hemodynamic changes during ephedrine and phenylephrine administration for transient intraoperative hypotension in patients undergoing major abdominal surgery: a randomized controlled trial
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DOI: 10.1186/s12871-025-02944-z
Abstract: Phenylephrine and ephedrine are frequently used vasopressors for treating intraoperative hypotension. However, their impact on cerebral oxygenation and blood flow remains a subject of debate. This study aims to understand their effects on cerebral oxygen… read more here.
Keywords: phenylephrine; hemodynamics; hypotension; administration ... See more keywords
Effect of crystalloid solution co-loading infusion rate on the dose requirements of prophylactic phenylephrine for preventing hypotension following combined spinal-epidural anesthesia for cesarean delivery
Sign Up to like & getrecommendations! Published in 2024 at "BMC Pregnancy and Childbirth"
DOI: 10.1186/s12884-024-06937-7
Abstract: Intravenous fluid administration and prophylactic vasopressor infusion are the primary methods for preventing spinal anesthesia-induced hypotension during cesarean delivery. However, evidence regarding the impact of different volumes of crystalloid solution on the phenylephrine infusion dosage… read more here.
Keywords: hypotension; group; infusion; cesarean delivery ... See more keywords
Effect of norepinephrine and phenylephrine on prothrombotic response in patients undergoing cesarean section under spinal anesthesia: protocol for a randomized, double-blind, controlled study
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DOI: 10.1186/s13063-024-08255-x
Abstract: Background Norepinephrine and phenylephrine are commonly used vasoactive drugs to treat hypotension during the perioperative period. The increased release of endogenous norepinephrine elicits prothrombotic changes, while parturients are generally in a hypercoagulable state. Therefore, this… read more here.
Keywords: patients undergoing; prothrombotic response; trial; norepinephrine phenylephrine ... See more keywords