Phenylephrine infusion impact on surgical site infections after lower extremity bypass surgery
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2017.05.130
Abstract: Objective Lower extremity bypass (LEB) operations have high rates of surgical site infections (SSI). Phenylephrine is a commonly used vasoconstrictor which may reduce skin blood flow and increase the likelihood of SSI in these patients.… read more here.
Keywords: lower extremity; surgery; phenylephrine infusion; phenylephrine ... See more keywords
An open‐label, randomized, four‐treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.04.008
Abstract: ABSTRACT Phenylephrine hydrochloride (HCl) is a decongestant available in over‐the‐counter (OTC) medicines. Previously marketed prescription products contained phenylephrine tannate, an extended‐release salt, which allowed dosing every 8–12 h. Given the regulatory history that cold medicines… read more here.
Keywords: salt; acetaminophen; crossover study; hcl ... See more keywords
A Random-allocation Graded Dose-Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001880
Abstract: BACKGROUND Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However,… read more here.
Keywords: dose response; response; spinal anesthesia; cesarean delivery ... See more keywords
A randomised controlled trial of phenylephrine and noradrenaline boluses for treatment of postspinal hypotension during elective caesarean section
Sign Up to like & getrecommendations! Published in 2019 at "Anaesthesia"
DOI: 10.1111/anae.14675
Abstract: Phenylephrine is currently the vasopressor of choice during elective caesarean section, but it can cause reflex bradycardia. Noradrenaline, a potent α‐agonist and weak β‐agonist, may be associated with a lower incidence of bradycardia. However, comparative… read more here.
Keywords: postspinal hypotension; elective caesarean; phenylephrine noradrenaline; phenylephrine ... See more keywords
Does Switching Norepinephrine to Phenylephrine in Septic Shock Complicated by Atrial Fibrillation With Rapid Ventricular Response Improve Time to Rate Control?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Intensive Care Medicine"
DOI: 10.1177/0885066619896292
Abstract: Background: Atrial fibrillation (AF) frequently develops during critical illness. In septic shock complicated by rapid AF, the use of phenylephrine may be advantageous secondary to its β-1 sparing properties. However, evidence supporting this strategy is… read more here.
Keywords: phenylephrine; septic shock; rate; rate control ... See more keywords
Fluid vs. Phenylephrine: Compartment Syndrome in the Hand Following Massive Volume Resuscitation
Sign Up to like & getrecommendations! Published in 2020 at "HAND"
DOI: 10.1177/1558944720966738
Abstract: We thank the authors for the report on compartment syndrome in the hand of a patient following phenylephrine infusion.1 There are several aspects of the case that we believe require careful consideration before concluding that… read more here.
Keywords: compartment syndrome; fluid; hand; resuscitation ... See more keywords
Application of Racemization Process to Dynamic Resolution of (RS)-Phenylephrine to (R)-Phenylephrine β-D-Glucoside by Nicotiana tabacum Glucosyltransferase
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801301113
Abstract: Enzymatic glucosylation of racemic phenylephrine by glucosyltransferase from Nicotiana tabacum gave (R)-phenylephrine glucoside and recovered (S)-phenylephrine. [RuCl2(p-cymene)]2 complex associated with simple hemisalen ligands or zeolite were able to racemize (S)-phenylephrine. The [RuCl2(p-cymene)]2/Ligand/TEMPO or zeolite racemization… read more here.
Keywords: racemization; glucosyltransferase; nicotiana tabacum; phenylephrine ... See more keywords
Prophylactic Norepinephrine and Phenylephrine Boluses to Prevent Postspinal Anesthesia Hypotension During Cesarean Section: A Randomized Sequential Allocation Dose-Finding Study
Sign Up to like & getrecommendations! Published in 2023 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s406671
Abstract: Background Norepinephrine and phenylephrine are widely used for obstetric anesthesia. Our central objective was to determine the ED (effective dose) 90 and potency ratio of prophylactic norepinephrine and phenylephrine boluses for preventing postspinal anesthesia hypotension… read more here.
Keywords: norepinephrine phenylephrine; postspinal anesthesia; anesthesia; anesthesia hypotension ... See more keywords
A routine Over the counter phenylephrine causing rarer drug eruption as Adverse drug reaction - A case report.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug safety"
DOI: 10.2174/1574886318666230601162144
Abstract: BACKGROUND Phenylephrine is a sympathomimetic, which means it acts analogous to adrenaline. Phenylephrine can be taken orally to treat nasal congestion symptoms. It is also frequently mixed with other medicines in products meant to relieve… read more here.
Keywords: case; drug eruption; eruption adverse; drug ... See more keywords
Prophylactic Phenylephrine Increases the Dose Requirement of Oxytocin to Treat Uterine Atony During Cesarean Delivery: A Double-Blinded, Single-Center, Randomized and Placebo-Controlled Trial
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.720906
Abstract: Purpose: Studies involving mouse models and human uterine smooth muscle cells have shown that phenylephrine inhibits uterine contractions in non-pregnant mice and human in vitro cell via cyclic adenosine monophosphate (cAMP) signaling. However, there has… read more here.
Keywords: infusion; control; delivery; group ... See more keywords
Determination of the Relative Potency of Norepinephrine and Phenylephrine Given as Infusions for Preventing Hypotension During Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Up-And-Down Sequential Allocation Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.942005
Abstract: Purpose: The relative potency of norepinephrine and phenylephrine given as boluses to treat hypotension during spinal anesthesia for cesarean delivery has been reported but few data are available for infusions. This study aimed to determine… read more here.
Keywords: hypotension; norepinephrine phenylephrine; relative potency; infusion ... See more keywords