Stereoselective Total Synthesis of (6S)-5,6-Dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one from L-Malic Acid
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DOI: 10.1177/1934578x1801300721
Abstract: A stereoselective total synthesis of an antiproliferative and antifungal natural product, (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one has been accomplished using the Barbier allylation, LiAlH4/LiI mediated syn-stereoselective reduction and olefin ring-closing metathesis (RCM) as the key steps. L-Malic acid was… read more here.
Keywords: phenylhexyl pyran; stereoselective total; total synthesis; pyran one ... See more keywords