Crystallographic studies of cinnamamide derivatives as a means of searching for anticonvulsant activity.
Sign Up to like & getrecommendations! Published in 2017 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229617013845
Abstract: A cinnamamide (3-phenylprop-2-enamide) core is present in many pharmacologically active compounds. We report three new crystal structures of N-substituted cinnamamide derivatives which were screened for anticonvulsant activity, namely (R,S)-(2E)-N-(2-hydroxypropyl)-3-phenylprop-2-enamide, C12H15NO2, (1), (R,S)-(2E)-N-(1-hydroxybutan-2-yl)-3-phenylprop-2-enamide, C13H17NO2, (2), and… read more here.
Keywords: anticonvulsant activity; cinnamamide derivatives; phenylprop enamide; studies cinnamamide ... See more keywords
Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides
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DOI: 10.3390/ijms19082318
Abstract: A series of sixteen ring-substituted N-arylcinnamamides was prepared and characterized. Primary in vitro screening of all the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium tuberculosis H37Ra, Fusarium avenaceum, and… read more here.
Keywords: spectrum biological; biological activities; phenylprop enamide; activities novel ... See more keywords
Insights into Antimalarial Activity of N-Phenyl-Substituted Cinnamanilides
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DOI: 10.3390/molecules27227799
Abstract: Due to the urgent need of innovation in the antimalarial therapeutic arsenal, a series of thirty-seven ring-substituted N-arylcinnamanilides prepared by microwave-assisted synthesis were subjected to primary screening against the chloroquine-sensitive strain of P. falciparum 3D7/MRA-102.… read more here.
Keywords: insights antimalarial; antimalarial activity; phenyl; phenylprop enamide ... See more keywords