α-(phenylselanyl) acetophenone abolishes acute restraint stress induced-comorbid pain, depression and anxiety-related behaviors in mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.08.006
Abstract: &NA; &agr;‐(phenylselanyl) acetophenone (PSAP) is an organoselenium compound that presents antidepressive‐like and antinociceptive effect in animal models. In this study, we evaluate the potential pharmacological effects of PSAP on acute stress restriction (ARS)‐induced depressive and… read more here.
Keywords: acute restraint; phenylselanyl acetophenone; psap; stress ... See more keywords
Lipopolysaccharide-induced depressive-like, anxiogenic-like and hyperalgesic behavior is attenuated by acute administration of α-(phenylselanyl) acetophenone in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.11.028
Abstract: ABSTRACT The lipopolysaccharide (LPS) is an endotoxin derived from gram‐negative bacteria, which induces inflammation. The aims of this study were to evaluate the possible &agr;‐(phenylselanyl) acetophenone (PSAP) activity in reducing comorbid hyperalgesia, depressive‐like and anxiogenic‐like… read more here.
Keywords: anxiogenic like; phenylselanyl acetophenone; like anxiogenic; psap ... See more keywords