Does long‐term phenytoin have a place in Dravet syndrome?
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51684
Abstract: Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet… read more here.
Keywords: long term; syndrome long; term phenytoin; dravet syndrome ... See more keywords
Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-02979-3
Abstract: The transient receptor potential vanilloid-1 (TRPV1) receptor has been implicated in the development of epileptic seizures. We examined the effect of the TRPV1 agonist capsaicin on epileptic seizures, neuronal injury and oxidative stress in a… read more here.
Keywords: capsaicin; phenytoin capsaicin; capsaicin phenytoin; capsaicin exerts ... See more keywords
Phenytoin-loaded bioactive nanoparticles for the treatment of diabetic pressure ulcers: formulation and in vitro/in vivo evaluation.
Sign Up to like & getrecommendations! Published in 2022 at "Drug delivery and translational research"
DOI: 10.1007/s13346-022-01156-z
Abstract: Drug repurposing offers the chance to explore the full potential of existing drugs while reducing drug development time and costs. For instance, the anticonvulsant drug phenytoin (PHT) has been investigated for its wound healing properties.… read more here.
Keywords: wound healing; treatment diabetic; drug; pressure ulcers ... See more keywords
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.04.002
Abstract: OBJECTIVE Gingival overgrowth is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressants, and calcium channel blockers. One of the main drugs associated with gingival overgrowth is the antiepileptic phenytoin,… read more here.
Keywords: sos1 gene; gingival overgrowth; phenytoin; overgrowth ... See more keywords
The predictive performances of equations used to estimate unbound phenytoin concentrations in a medical ICU population and the impact of exogenous albumin administration☆
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2017.10.028
Abstract: Purpose: This study evaluated the predictive performances of four equations (Sheiner‐Tozer [ST], Kane‐modified ST, Anderson‐modified ST, and Cheng‐modified ST) used to estimate free phenytoin concentrations in a medical intensive care unit (MICU) and assessed the… read more here.
Keywords: unbound phenytoin; exogenous albumin; phenytoin; albumin administration ... See more keywords
Rapid infusion of excessive phenytoin: A newborn autopsy case.
Sign Up to like & getrecommendations! Published in 2021 at "Legal medicine"
DOI: 10.1016/j.legalmed.2021.101935
Abstract: The patient was a two-day-old female infant. The patient's mother was a primigravid in her 20 s who developed premature abruption of the normal placenta on the first day of the 33rd week of gestation. The… read more here.
Keywords: rapid infusion; case; phenytoin; autopsy ... See more keywords
Critical Excipient Properties for the Dissolution Enhancement of Phenytoin
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DOI: 10.1021/acsomega.9b02383
Abstract: Solubility-enhancing amorphous solid dispersions can aid in the oral delivery of hydrophobic, poorly soluble drugs. Effective solid dispersion excipients enable high supersaturation drug concentrations over biologically relevant time scales. The critical characteristics of an excipient… read more here.
Keywords: excipient properties; properties dissolution; solid dispersions; phenytoin ... See more keywords
Phenytoin and damage to the cerebellum – a systematic review of published cases
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2022.2058487
Abstract: ABSTRACT Introduction The antiseizure medication phenytoin has been associated with changes in the cerebellum, cerebellar signs, and permanent cerebellar damage. We have systematically reviewed the clinical and radiological features, and their correlation. Areas covered We… read more here.
Keywords: cerebellar atrophy; damage; damage cerebellum; phenytoin damage ... See more keywords
Phenytoin Induced Chorea: A Case Report.
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000562
Abstract: To the Editor: Phenytoin is a common anticonvulsant and it acts by blocking the voltage dependent block of voltage gated sodium channels.1 Phenytoin is mainly metabolized in the liver by CYP2C9 and individuals with impaired… read more here.
Keywords: phenytoin induced; induced chorea; case; phenytoin ... See more keywords
Impact of drug‐drug interactions on phenobarbital pharmacokinetics in pediatric patients
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsia"
DOI: 10.1111/epi.14704
Abstract: To the Editors: We have read with great interest the article “Phenobarbital population pharmacokinetics across the pediatric age spectrum” by Moffett et al.1 The authors concluded that midazolam, phenytoin, and pantoprazole significantly affected phenobarbital clearance… read more here.
Keywords: phenobarbital pharmacokinetics; drug; phenytoin; moffett ... See more keywords
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of periodontal research"
DOI: 10.1111/jre.12750
Abstract: BACKGROUND AND OBJECTIVE Human gingival fibrolasts aging is an important cause of periodontal disease. Phenytoin sodium (phenytoin) has a side effect of gingival hyperplasia and an effect on the autophagy progress. This study investigated whether… read more here.
Keywords: fibroblast; phenytoin sodium; phenytoin; effect ... See more keywords