Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions
Sign Up to like & getrecommendations! Published in 2020 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2020.100488
Abstract: Background Smoking is one of the greatest threats to public health worldwide. We integrated phenome-wide association study (PheWAS) and Mendelian randomization (MR) approaches to explore causal effects of genetically predicted smoking intensity across the human… read more here.
Keywords: phewas; smoking intensity; mendelian randomization; intensity ... See more keywords
Methodology in phenome-wide association studies: a systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-107696
Abstract: Phenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims to summarise the PheWAS methodology, discuss the advantages and challenges of PheWAS,… read more here.
Keywords: phewas; methodology; phenome wide; systematic review ... See more keywords