PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis
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DOI: 10.1126/sciadv.aaz0356
Abstract: PHF20L1, a H3K27me2 reader, promotes breast tumorigenesis by cooperating with the PRC2/NuRD complex. TUDOR domain–containing proteins (TDRDs) are chiefly responsible for recognizing methyl-lysine/arginine residue. However, how TDRD dysregulation contributes to breast tumorigenesis is poorly understood.… read more here.
Keywords: phf20l1 h3k27me2; tumorigenesis; breast tumorigenesis; h3k27me2 reader ... See more keywords