Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials.
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DOI: 10.1182/bloodadvances.2019000391
Abstract: Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, a congenital neurodevelopmental disorder. Loss-of-function mutations of PHF6 are detected in… read more here.
Keywords: phf6; phf6 knockout; renewal capacity; self renewal ... See more keywords