Structure‐Based Design of a New Scaffold for Cell‐Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700109
Abstract: The histone demethylase PHF8 catalyzes demethylation of mono‐ and di‐methylated Lys9 on histone H3 (H3K9me1/2), and is a transcriptional activator involved in the development and cancer. Affinity and specificity of PHF8 towards H3K9me2 is affected… read more here.
Keywords: demethylase phf8; histone demethylase; structure based; cell penetrating ... See more keywords
Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer letters"
DOI: 10.1016/j.canlet.2022.01.010
Abstract: The DNA damage response (DDR) pathway generally protects against genome instability, and defects in DDR have been exploited therapeutically in cancer treatment. We have reported that histone demethylase PHF8 demethylates TOPBP1 K118 mono-methylation (K118me1) to… read more here.
Keywords: breast tumor; phf8 topbp1; phf8; tumor specific ... See more keywords
Abstract B30: The histone demethylase PHF8 epigenetically regulates the TGFbeta pathway to promote melanoma metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.mel2019-b30
Abstract: The specific contribution of epigenetic dysregulation to the metastatic process remains understudied. Through a meta-analysis of gene expression datasets followed by a functional mini-screen, we identified PHF8, a histone demethylase of the Jumonji C proteins… read more here.
Keywords: demethylase; phf8 epigenetically; demethylase phf8; histone demethylase ... See more keywords
Expression Patterns of PAK4 and PHF8 Are Associated with the Survival of Gallbladder Carcinoma Patients
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DOI: 10.3390/diagnostics13061149
Abstract: Background: PAK4 and PHF8 are involved in cancer progression and are under evaluation as targets for cancer therapy. However, despite extensive studies in human cancers, there are limited reports on the roles of PAK4 and… read more here.
Keywords: pak4 phf8; gallbladder carcinoma; phf8; expression ... See more keywords
Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome
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DOI: 10.3390/genes14010172
Abstract: The majority of pseudogenes are generated when an RNA transcript is reverse-transcribed and integrated into the genome at a new location. Pseudogenes are often considered as an imperfect and silent copy of a functional gene… read more here.
Keywords: pseudogene; phf8; mouse genome; pseudogene mouse ... See more keywords
PHF8 Plays an Oncogene Function in Hepatocellular Carcinoma Formation.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology research"
DOI: 10.3727/096504018x15410353669149
Abstract: Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and the number of new cases and deaths from liver cancer are increasing. However, the details of the regulation in HCC remain largely unknown. Plant homeodomain… read more here.
Keywords: hepatocellular carcinoma; hcc; formation; phf8 ... See more keywords