Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.
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DOI: 10.1016/j.canlet.2022.01.010
Abstract: The DNA damage response (DDR) pathway generally protects against genome instability, and defects in DDR have been exploited therapeutically in cancer treatment. We have reported that histone demethylase PHF8 demethylates TOPBP1 K118 mono-methylation (K118me1) to… read more here.
Keywords: breast tumor; phf8 topbp1; phf8; tumor specific ... See more keywords