Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202205818
Abstract: Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, impairment of Phgdh enzyme… read more here.
Keywords: nuclear phgdh; phgdh; elevated nuclear; liver cancer ... See more keywords
Mild phenotypes of phosphoglycerate dehydrogenase deficiency by a novel mutation of PHGDH gene: Case report and literature review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10236
Abstract: Phosphoglycerate dehydrogenase (PHGDH) deficiency is a rare autosomal recessive genetic disease of serine biosynthesis. Its typical features are congenital microcephaly, epileptic seizures, and psychomotor developmental delay. Here, we reported the first Chinese familial cases with… read more here.
Keywords: mutation phgdh; phgdh; deficiency; phosphoglycerate dehydrogenase ... See more keywords
Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105705
Abstract: Phosphoglycerate dehydrogenase (PHGDH) is abnormally expressed in numerous malignant tumor cells and catalyzes the first step of serine biosynthesis, thus becoming a key drug target for antitumor treatment. In this study, compound B2 bearing a… read more here.
Keywords: study; phgdh; structure activity; activity ... See more keywords
The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.086
Abstract: NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein,… read more here.
Keywords: serine biosynthesis; salvage pathway; nad salvage; salvage ... See more keywords
Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.154000
Abstract: OBJECTIVE Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about serine metabolism in fatty liver disease (FLD). We aimed to investigate the changes in serine biosynthetic… read more here.
Keywords: fatty liver; serine; expression; liver disease ... See more keywords
Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "Poultry Science"
DOI: 10.1016/j.psj.2022.101805
Abstract: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear. We report that the expression of PHGDH increased significantly during proliferation of… read more here.
Keywords: muscle; proliferation chicken; phgdh; chicken muscle ... See more keywords
3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00990
Abstract: The enzymatic mechanism of 3-phosphoglycerate to 3-phosphohydroxypyruvate oxidation, which forms the first step of the main conserved de novo serine synthesis pathway, has been revisited recently in certain microorganisms. While this step is classically considered… read more here.
Keywords: phosphoglycerate; serine synthesis; yeast; novo serine ... See more keywords
PHGDH promotes the proliferation and differentiation of primary chicken myoblasts
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2062221
Abstract: ABSTRACT 1. Chicken primary myoblasts (CPMs) are precursors that form muscle fibres. The proliferation and differentiation of CPMs is an essential stage in muscle development. Previous RNA-seq analysis showed that phosphoglycerate dehydrogenase (PHGDH) is a… read more here.
Keywords: effect; phgdh; chicken; differentiation ... See more keywords
Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27186108
Abstract: Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3-Phosphohydroxy pyruvate… read more here.
Keywords: phgdh; identification; phosphoglycerate dehydrogenase; acid ... See more keywords
Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation
Sign Up to like & getrecommendations! Published in 2021 at "Nutrients"
DOI: 10.3390/nu13103468
Abstract: l-Serine (Ser) is synthesized de novo from 3-phosphoglycerate via the phosphorylated pathway committed by phosphoglycerate dehydrogenase (Phgdh). A previous study reported that feeding a protein-free diet increased the enzymatic activity of Phgdh in the liver… read more here.
Keywords: protein; protein starvation; lko mice; mice ... See more keywords
PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.74546
Abstract: Background: Bladder cancer (BCa) is a prevalent urologic malignancy that shows a poor prognosis. Abnormal metabolism and its key genes play a critical role in BCa progression. In this study, the role played by PhosphoGlycerol… read more here.
Keywords: inhibits ferroptosis; bca; phgdh; progression ... See more keywords