The PHGDH enigma: do cancer cells only need serine or also a redox modulator?
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DOI: 10.1016/j.canlet.2020.01.036
Abstract: Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers… read more here.
Keywords: phgdh enigma; enigma cancer; serine; cancer cells ... See more keywords