Abstract 1627: PHI-501, a novel and potent pan-RAF inhibitor in metastatic melanoma
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DOI: 10.1158/1538-7445.am2023-1627
Abstract: Background: PHI-501 has been developed as a novel inhibitor of NRAS mutated acute myeloid leukemia. Big data and artificial intelligence (AI)-based drug discovery platform and cell-based investigation identified PHI-501 repurposable against melanoma as a novel… read more here.
Keywords: cell; melanoma; inhibitor; pan raf ... See more keywords
Abstract 411: PHI-501, a novel pan-RAF/DDRs dual kinase inhibitor, overcomes BRAF or MEK inhibitor resistance in melanoma
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DOI: 10.1158/1538-7445.am2023-411
Abstract: Background: PHI-501 is a newly developed, highly effective, and orally accessible dual inhibitor for pan-RAF and discoidin domain receptor (DDR) that is a collagen-activated receptor tyrosine kinase. Mutations of the BRAF and NRAS are the… read more here.
Keywords: pan raf; phi 501; inhibitor; melanoma ... See more keywords