Virtual screening of p53 mutants reveals Y220S as an additional rescue drug target for PhiKan083 with higher binding characteristics
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DOI: 10.1016/j.compbiolchem.2019.05.005
Abstract: Pharmacological intervention to reactivate p53 in human tumors holds great promise for cancer patients. A number of small molecules that reactivate p53 mutants that are either specific to certain mutation or more broadly on various… read more here.
Keywords: target; p53 mutants; drug; interaction ... See more keywords