The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia‐negative B‐cell acute lymphoblastic leukemia is a strong predictor for survival
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DOI: 10.1002/ajh.25671
Abstract: The minimal or measurable residual disease (MRD) status following induction/consolidation chemotherapy is an important prognostic endpoint in adult patients with newly diagnosed acute lymphoblastic leukemia (ALL). However, the optimal time‐point (TP) of MRD assessment and… read more here.
Keywords: mrd; philadelphia negative; lymphoblastic leukemia; measurable residual ... See more keywords
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
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DOI: 10.1016/j.htct.2017.12.003
Abstract: Background Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods This study examined the plasma cytokine profiles… read more here.
Keywords: neoplasms disorders; philadelphia negative; primary myelofibrosis; negative myeloproliferative ... See more keywords
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.
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DOI: 10.1016/j.leukres.2017.12.005
Abstract: BACKGROUND Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the clinical phenotype of MPN patients… read more here.
Keywords: philadelphia negative; negative myeloproliferative; calr; calr mutations ... See more keywords
Clinical value of RAG1 expression and IKZF1 deletions in Philadelphia negative pediatric B cell precursor acute lymphoblastic leukemia
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DOI: 10.1080/08880018.2020.1767739
Abstract: Abstract This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia… read more here.
Keywords: cell; philadelphia negative; rag1 expression; expression ... See more keywords
Retrospective chart review of hospitalizations and costs associated with the treatment of adults with Philadelphia-negative B-cell relapsed or refractory acute lymphoblastic leukemia in Belgium
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DOI: 10.1080/17843286.2017.1314091
Abstract: Objectives: To quantify hospitalizations and costs among adults with Philadelphia-negative relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (ALL) who received current salvage chemotherapies in Belgium. Methods: A retrospective chart review identified patients aged ≥18… read more here.
Keywords: chemotherapy; adults philadelphia; philadelphia negative; salvage ... See more keywords
Successful Treatment of Adolescents and Young Adults with Philadelphia-Negative Acute Lymphoblastic Leukemia by Novel L-Asparaginase-Intensified Induction Therapy and Cord Blood Transplantation: A Single-Center Decade Report.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of adolescent and young adult oncology"
DOI: 10.1089/jayao.2017.0120
Abstract: A novel induction therapy, including intensive L-asparaginase, was designed in 2007 for patients aged read more here.
Keywords: philadelphia negative; induction therapy; negative acute; acute lymphoblastic ... See more keywords
Second malignancies in hydroxyurea and interferon‐treated Philadelphia‐negative myeloproliferative neoplasms
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DOI: 10.1111/ejh.12787
Abstract: In an era of controversy in regard to ‘hydroxyurea‐leukaemogenicity’ and when interferon‐alfa2 (IFN) is being revived in the treatment of Philadelphia‐negative myeloproliferative neoplasms (MPNs), we aim in this single‐centre observational study to describe the frequencies… read more here.
Keywords: second malignancies; philadelphia negative; negative myeloproliferative; hydroxyurea interferon ... See more keywords
Characteristics and outcomes of young adults with Philadelphia‐negative myeloproliferative neoplasms
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DOI: 10.1111/ejh.13232
Abstract: Approximately 10% of Philadelphia (Ph)‐negative myeloproliferative neoplasms (NPM) are diagnosed at young adulthood. We aim to define the features of this group. read more here.
Keywords: philadelphia negative; negative myeloproliferative; characteristics outcomes; outcomes young ... See more keywords
Methylation of the suppressor of Cytokine Signaling 1 Gene (SOCS1) in Philadelphia-negative myeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202211_30381
Abstract: OBJECTIVE Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation is initiated by mutations in the JAK2 gene. This activation is in turn, a vital pathogenetic mechanism in myeloproliferative neoplasms (MPNs). However, several factors… read more here.
Keywords: jak stat; methylation; philadelphia negative; cytokine signaling ... See more keywords
Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia
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DOI: 10.3324/haematol.2018.208801
Abstract: Clonal chromosome abnormalities in Philadelphia-negative cells could concern chronic myeloid leukemia patients treated by tyrosine kinase inhibitors. The European LeukemiaNet distinguishes -7/del(7q) abnormalities as a “warning”. However, the impact of clonal chromosome abnormalities, and specifically… read more here.
Keywords: myeloid leukemia; clonal chromosome; chromosome; philadelphia negative ... See more keywords
Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms
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DOI: 10.3390/cancers12030573
Abstract: The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the… read more here.
Keywords: ocular manifestations; philadelphia negative; negative myeloproliferative; patients philadelphia ... See more keywords