Continuous Radio Amplification by Stimulated Emission of Radiation using Parahydrogen Induced Polarization (PHIP‐RASER) at 14 Tesla
Sign Up to like & getrecommendations! Published in 2020 at "Chemphyschem"
DOI: 10.1002/cphc.201901056
Abstract: Abstract Nuclear Magnetic Resonance (NMR) is an intriguing quantum‐mechanical effect that is used for routine medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents… read more here.
Keywords: phip; radio amplification; parahydrogen; amplification stimulated ... See more keywords
Hyphenation of 2D NMR With Hydrogenative PHIP
Sign Up to like & getrecommendations! Published in 2025 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.5510
Abstract: ABSTRACT Parahydrogen induced polarisation (PHIP) is often used to enhance the sensitivity of NMR, with the purpose of extending the applicability of the technique. Nuclear spin hyperpolarisation obtained via PHIP is generally localised on the… read more here.
Keywords: spectroscopy; methodology; hyphenation nmr; nmr hydrogenative ... See more keywords
Simultaneous determination of the PhIP-proline adduct and related precursors by UPLC-MS/MS for confirmation of direct elimination of PhIP by proline.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.130484
Abstract: The effect and elimination pathway of proline on reducing PhIP and the effect of processing temperature, duration, and proline addition on the PhIP-proline adduct and its precursors were investigated. The results have demonstrated that PhIP… read more here.
Keywords: phip; phip proline; proline adduct; elimination ... See more keywords
A highly versatile automatized setup for quantitative measurements of PHIP enhancements.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2017.10.007
Abstract: The design and application of a versatile and inexpensive experimental extension to NMR spectrometers is described that allows to carry out highly reproducible PHIP experiments directly in the NMR sample tube, i.e. under PASADENA condition,… read more here.
Keywords: phip; automatized setup; highly versatile; setup quantitative ... See more keywords
Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00426
Abstract: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine formed during the high-temperature cooking of meats. The cytochrome P450-mediated N-hydroxylation of the exocyclic amine group of PhIP produces 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, an electrophilic metabolite that forms adducts with… read more here.
Keywords: phip; acid labile; phenylimidazo pyridine; albumin ... See more keywords
Synergistic Inhibitory Effects of Selected Amino Acids on the Formation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in both Benzaldehyde- and Phenylacetaldehyde-Creatinine Model Systems.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03122
Abstract: Although various inhibitors have been employed to react with phenylacetaldehyde to form adducts and thus interrupt the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), high concentrations of PhIP remain in the final system. It remains unknown whether other… read more here.
Keywords: amino acids; phip formation; formation; model ... See more keywords
A novel PHIP variant in a family with severe early-onset obesity.
Sign Up to like & getrecommendations! Published in 2024 at "Hormone research in paediatrics"
DOI: 10.1159/000542205
Abstract: Abstract Introduction: Severe childhood obesity can be caused by pathogenic variants in several genes involved in monogenic and syndromic obesity. Recently, heterozygous variants in pleckstrin homology domain interacting protein (PHIP) have been identified in patients… read more here.
Keywords: phip variant; severe early; obesity; phip ... See more keywords
PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26341
Abstract: Recent studies have assigned novel roles to pleckstrin homology domain-interacting protein (PHIP) in tumor progression [1, 2]. PHIP was initially shown to operate in the insulin-like growth factor receptor 1 (IGF1R)/PI3K signaling pathway in normal… read more here.
Keywords: melanoma; phip; phip copy; copy number ... See more keywords
Inhibitory effects of cassiae semen extract on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in model system
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2024.1407007
Abstract: Introduction 2-Amino-1-methyl-6-phenylimidazole [4,5-b] pyridine (PhIP), a heterocyclic amine (HAA), is found in meat products heated at high temperatures. However, PhIP is a mutagenic and potential carcinogenic compound. Cassiae semen, a type of medicine and food… read more here.
Keywords: system; phip; model; cassiae semen ... See more keywords
Effect of Immersion Time of Chicken Breast in Potato Starch Coating Containing Lysine on PhIP Levels
Sign Up to like & getrecommendations! Published in 2024 at "Foods"
DOI: 10.3390/foods13020222
Abstract: This study investigated the effect of immersion time of chicken breasts in potato starch (PS) coating containing amino acids (AAs) on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) and to evaluate a possible mechanism to… read more here.
Keywords: potato starch; immersion time; starch coating; phip ... See more keywords
Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11050568
Abstract: Simple Summary Determining the exposure or infection history of a person to a multitude of viruses is not an easy task. Typically, antibody tests detect antibodies against proteins (antigens) to only one or a few… read more here.
Keywords: serology; technology; immunoprecipitation sequencing; phage immunoprecipitation ... See more keywords