Synthesis and characterization of pHLIP® coated gold nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.02.008
Abstract: Novel approaches in synthesis of spherical and multispiked gold nanoparticles coated with polyethylene glycol (PEG) and pH Low Insertion Peptide (pHLIP®) were introduced. The presence of a tumor-targeting pHLIP® peptide in the nanoparticle coating enhances… read more here.
Keywords: characterization phlip; tumor; coated gold; gold nanoparticles ... See more keywords
Phosphatidylserine Asymmetry Promotes the Membrane Insertion of a Transmembrane Helix.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.003
Abstract: The plasma membrane (PM) contains an asymmetric distribution of lipids between the inner and outer bilayer leaflets. A lipid of special interest in eukaryotic membranes is the negatively charged phosphatidylserine (PS). In healthy cells, PS… read more here.
Keywords: insertion; phlip; membrane insertion; asymmetry ... See more keywords
Differential Sensitivity of pHLIP to Ester and Ether Lipids.
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2019.104849
Abstract: pH (low) insertion peptide (pHLIP) is a polypeptide from the third transmembrane helix of bacteriorhodopsin. The pH-dependent membrane insertion of pHLIP has been conveniently exploited for translocation of cargo molecules and as a novel imaging… read more here.
Keywords: ester ether; ether lipids; phlip; ester ... See more keywords
Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel ICG-Var3 pHLIP Imaging Agent.
Sign Up to like & getrecommendations! Published in 2019 at "Urology"
DOI: 10.1016/j.urology.2019.01.008
Abstract: OBJECTIVES To improve visualization of upper tract urothelial carcinomas (UTUC). Previous studies using the novel pH low insertion peptide (pHLIP) variant 3 (Var3) conjugated to indocyanine green (ICG) have demonstrated high sensitivity and specificity for… read more here.
Keywords: phlip; var3; urothelial carcinoma; icg var3 ... See more keywords
Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00883
Abstract: Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, "drug-like" molecules. Here, we… read more here.
Keywords: insertion; delivery; phlip; drug ... See more keywords
Rationally Engineering a pH-Low Insertion Peptide Variant Probe for High-Sensitivity Imaging of Early Tumors.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c04650
Abstract: The detection of early stage tumors is essential in oncology but remains a formidable challenge. Here, we developed a fluorescent pH low insertion peptide (pHLIP) variant probe, 4 M pHLIP-Cy5.5, that can recognize the weak… read more here.
Keywords: phlip cy5; low insertion; sensitivity; phlip ... See more keywords
Abstract A102: pHLIP technology for targeting acidity at surface of tumor cells and extracellular and intracellular delivery of imaging and therapeutic agents
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a102
Abstract: pH-Low Insertion Peptides (pHLIP® peptides) are a platform technology for targeting of acidity at the surface of individual cells within tumors. Most proteins that are located across membranes have one or more helical segments that… read more here.
Keywords: technology targeting; acidity surface; phlip; acidity ... See more keywords
Abstract 3193: Utilizing a pH sensitive peptide (pHLIP) for antigen-directed T cell therapy
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3193
Abstract: Many targeted therapies, such as antibody drug conjugates (ADCs) and chimeric antigen receptor (CAR) T cell therapies, rely on the identification of an optimal antigen as the cell marker for targeting cancer cells. However, there… read more here.
Keywords: antigen; recognition; cell; tumor ... See more keywords
Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320296
Abstract: Background: miRNA therapeutics have gained attention during the past decade. These oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be used to correct the imbalance of gene expression found in human… read more here.
Keywords: phlip; atherosclerosis regression; using phlip; expression ... See more keywords
Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-018-2807-8
Abstract: Acidity at surface of cancer cells is a hallmark of tumor microenvironments, which does not depend on tumor perfusion, thus it may serve as a general biomarker for targeting tumor cells. We used the pH… read more here.
Keywords: low insertion; peptide phlip; phlip; insertion peptide ... See more keywords
Tumor treatment by pHLIP-targeted antigen delivery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1082290
Abstract: Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to tumors by pH… read more here.
Keywords: targeted antigen; phlip; low insertion; antigen delivery ... See more keywords