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   Articles with "phlip" as a keyword



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Synthesis and characterization of pHLIP® coated gold nanoparticles

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recommendations! Published in 2017 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2017.02.008

Abstract: Novel approaches in synthesis of spherical and multispiked gold nanoparticles coated with polyethylene glycol (PEG) and pH Low Insertion Peptide (pHLIP®) were introduced. The presence of a tumor-targeting pHLIP® peptide in the nanoparticle coating enhances… read more here.

Keywords: characterization phlip; tumor; coated gold; gold nanoparticles ... See more keywords
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Phosphatidylserine Asymmetry Promotes the Membrane Insertion of a Transmembrane Helix.

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recommendations! Published in 2019 at "Biophysical journal"

DOI: 10.1016/j.bpj.2019.03.003

Abstract: The plasma membrane (PM) contains an asymmetric distribution of lipids between the inner and outer bilayer leaflets. A lipid of special interest in eukaryotic membranes is the negatively charged phosphatidylserine (PS). In healthy cells, PS… read more here.

Keywords: insertion; phlip; membrane insertion; asymmetry ... See more keywords
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Differential Sensitivity of pHLIP to Ester and Ether Lipids.

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recommendations! Published in 2019 at "Chemistry and physics of lipids"

DOI: 10.1016/j.chemphyslip.2019.104849

Abstract: pH (low) insertion peptide (pHLIP) is a polypeptide from the third transmembrane helix of bacteriorhodopsin. The pH-dependent membrane insertion of pHLIP has been conveniently exploited for translocation of cargo molecules and as a novel imaging… read more here.

Keywords: ester ether; ether lipids; phlip; ester ... See more keywords
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Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel ICG-Var3 pHLIP Imaging Agent.

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recommendations! Published in 2019 at "Urology"

DOI: 10.1016/j.urology.2019.01.008

Abstract: OBJECTIVES To improve visualization of upper tract urothelial carcinomas (UTUC). Previous studies using the novel pH low insertion peptide (pHLIP) variant 3 (Var3) conjugated to indocyanine green (ICG) have demonstrated high sensitivity and specificity for… read more here.

Keywords: phlip; var3; urothelial carcinoma; icg var3 ... See more keywords
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Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.

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recommendations! Published in 2019 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.9b00883

Abstract: Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, "drug-like" molecules. Here, we… read more here.

Keywords: insertion; delivery; phlip; drug ... See more keywords
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Abstract A102: pHLIP technology for targeting acidity at surface of tumor cells and extracellular and intracellular delivery of imaging and therapeutic agents

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recommendations! Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-19-a102

Abstract: pH-Low Insertion Peptides (pHLIP® peptides) are a platform technology for targeting of acidity at the surface of individual cells within tumors. Most proteins that are located across membranes have one or more helical segments that… read more here.

Keywords: technology targeting; acidity surface; phlip; acidity ... See more keywords
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Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.121.320296

Abstract: Background: miRNA therapeutics have gained attention during the past decade. These oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be used to correct the imbalance of gene expression found in human… read more here.

Keywords: phlip; atherosclerosis regression; using phlip; expression ... See more keywords
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Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery

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recommendations! Published in 2018 at "Nanoscale Research Letters"

DOI: 10.1186/s11671-018-2807-8

Abstract: Acidity at surface of cancer cells is a hallmark of tumor microenvironments, which does not depend on tumor perfusion, thus it may serve as a general biomarker for targeting tumor cells. We used the pH… read more here.

Keywords: low insertion; peptide phlip; phlip; insertion peptide ... See more keywords
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Tumor treatment by pHLIP-targeted antigen delivery

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recommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2022.1082290

Abstract: Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to tumors by pH… read more here.

Keywords: targeted antigen; phlip; low insertion; antigen delivery ... See more keywords