Why is it so clean under the apple trees: discovery of novel phloretin derivatives as potential herbicidal agents
Sign Up to like & getrecommendations! Published in 2025 at "Pest Management Science"
DOI: 10.1002/ps.8745
Abstract: Weeds are a serious problem in worldwide agricultural production. Natural products are a notable source for discovering new lead compounds. Phloretin is a dihydrochalcone compound which was discovered in 1835 and named after its concentrated… read more here.
Keywords: phloretin; phloretin derivatives; novel phloretin; clean apple ... See more keywords
Solubilization of phloretin via steviol glycoside-based solid dispersion and micelles.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.125569
Abstract: In this study, the solubility of phloretin (PT) was enhanced via steviol glycoside (STE)-based micelle (MC) and solid dispersion (SD). Computer simulation, characterization, interaction with serum albumin (SA) and in vitro release were carried out… read more here.
Keywords: ste; phloretin; via steviol; solid dispersion ... See more keywords
Antibacterial activity, safety and preservative effect of aminoethyl-phloretin on the quality parameters of salmon fillets
Sign Up to like & getrecommendations! Published in 2020 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2019.108874
Abstract: Abstract Aminoethyl-phloretin (AEP), a novel water-soluble phloretin derivative, was synthesized from phloretin and 2-bromine ethylamine. Its antibacterial activity, safety, and preservative effect on salmon were studied. The structure of AEP was verified with UV, IR,… read more here.
Keywords: phloretin; aminoethyl phloretin; activity safety; antibacterial activity ... See more keywords
Molecular model and in vitro antioxidant activity of a water-soluble and stable phloretin/hydroxypropyl-β-cyclodextrin inclusion complex
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.03.098
Abstract: Abstract Phloretin, a dihydrochalcone flavonoid, has been associated with a wide range of biological properties such as antioxidation, antitumor, antidiabetes, skin whiting, etc. However, the instability and aqueous insolubility in its native form decreases its… read more here.
Keywords: hydroxypropyl cyclodextrin; phloretin; phloretin hydroxypropyl; inclusion complex ... See more keywords
Biocatalytic Production of a Potent Inhibitor of Adipocyte Differentiation from Phloretin Using Engineered CYP102A1.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c03156
Abstract: In this study, we investigated an efficient enzymatic strategy for producing potentially valuable phloretin metabolites from phlorizin, a glucoside of phloretin that is rich in apple pomace. Almond β-glucosidase efficiently removed phlorizin's glucose moiety to… read more here.
Keywords: potent inhibitor; phloretin; production; inhibitor adipocyte ... See more keywords
De Novo Artificial Biosynthesis of 3-Hydroxyphloretin in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c01962
Abstract: 3-Hydroxyphloretin (3-OH phloretin), a dihydrochalcone compound containing a catechol moiety, is naturally present in apples and exhibits potent anti-adipogenic, anti-obesity, and anticancer activities. In this study, we developed a modular co-culture platform enabling the de… read more here.
Keywords: phloretin; escherichia coli; phloretic acid; culture ... See more keywords
Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00750b
Abstract: Phloretin (Phl) is a natural flavonoid compound with wide range of biological activities but demonstrates poor water solubility and limited pharmacological effects. In this study, one cocrystal of phloretin–isoniazid (Phl–Inz) was prepared successfully using the… read more here.
Keywords: preparation characterization; phloretin; cocrystal; isoniazid preparation ... See more keywords
Biodegradable polymeric nanocomposite containing phloretin for enhanced oral bioavailability and improved myocardial ischaemic recovery
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2024.2418608
Abstract: Abstract Aim The study aimed to enhance phloretin’s oral absorption and systemic availability through nanoencapsulation within biodegradable polymers, improving its anti-oxidant and cardioprotective potential. Methods Phloretin-loaded polymeric nanocomposites were prepared using ionic gelation and optimised… read more here.
Keywords: phloretin; enhanced oral; drug; phloretin enhanced ... See more keywords
Phloretin inhibited the pathogenicity and virulence factors against Candida albicans.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1933824
Abstract: Oral candidiasis is one of the most common types of fungal infection caused by Candida albicans (C. albicans). The present study aims to investigate the antifungal effects of phloretin (a dihydrochalcone flavonoid) against the C.… read more here.
Keywords: virulence factors; candida albicans; phloretin; pathogenicity virulence ... See more keywords
Phloretin attenuates hyperuricemia‐induced endothelial dysfunction through co‐inhibiting inflammation and GLUT9‐mediated uric acid uptake
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13176
Abstract: Hyperuricemia is an important risk factor for cardiovascular and renal diseases. Phloretin had shown antioxidant and anti‐inflammatory properties, but its role in endothelial injury is rarely reported. In this study, we aimed to investigate the… read more here.
Keywords: phloretin; vein endothelial; inflammation; human umbilical ... See more keywords
New Insights Into the Activity of Apple Dihydrochalcone Phloretin: Disturbance of Auxin Homeostasis as Physiological Basis of Phloretin Phytotoxic Action
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.875528
Abstract: Apple species are the unique naturally rich source of dihydrochalcones, phenolic compounds with an elusive role in planta, but suggested auto-allelochemical features related to “apple replant disease” (ARD). Our aim was to elucidate the physiological… read more here.
Keywords: physiological basis; phloretin; apple; auxin ... See more keywords