PHLPP1/Nrf2-Mdm2 axis induces renal apoptosis via influencing nucleo-cytoplasmic shuttling of FoxO1 during diabetic nephropathy.
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DOI: 10.1007/s11010-021-04177-3
Abstract: Impaired PI3K/Akt signaling (insulin resistance) and poor glycemic control (hyperglycemia) are the major risk factors involved in the progression of diabetic nephropathy (DN). This study was designed to identify factors influencing cell survival during DN.… read more here.
Keywords: phlpp1; apoptosis; mdm2; foxo1 ... See more keywords