PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
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DOI: 10.1016/j.isci.2022.103766
Abstract: Summary Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-exposed… read more here.
Keywords: accumulation; fatty acid; phlpp1 promotes; chrebp ... See more keywords