Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans
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DOI: 10.1128/mbio.03551-22
Abstract: Invasive fungal diseases cause more than 1.5 million deaths per year, with an estimated 181,000 of these deaths attributable to Cryptococcal meningitis. Despite the high mortality, treatment options are limited. ABSTRACT Fungal pathogens uniquely regulate… read more here.
Keywords: phosphate; pho80; pho81; pho pathway ... See more keywords
A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae
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DOI: 10.1371/journal.pone.0176085
Abstract: Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient Pi. Pi-limitation induces upregulation… read more here.
Keywords: genes involved; saccharomyces cerevisiae; phosphate availability; inorganic phosphate ... See more keywords