Effect-Directed Synthesis of PhoP/PhoQ Inhibitors to Regulate Salmonella Virulence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01087
Abstract: Salmonella spp. are among the leading bacterial causes of foodborne infections. The PhoP/PhoQ two-component regulatory system serves as a master virulence regulator in Salmonella. Although PhoP/PhoQ represents an ideal target for disarming Salmonella virulence, it… read more here.
Keywords: phop phoq; salmonella virulence; directed synthesis; effect directed ... See more keywords
Serratia marcescens RamA Expression Is under PhoP-Dependent Control and Modulates Lipid A-Related Gene Transcription and Antibiotic Resistance Phenotypes
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DOI: 10.1128/jb.00523-20
Abstract: We demonstrate that in S. marcescens, the transcriptional regulator RamA is autoregulated and also controlled by the PhoP/PhoQ signal transduction system. We have shown that PhoP is able to directly and specifically bind to ramA,… read more here.
Keywords: lpxo2; rama; phop phoq; marcescens rama ... See more keywords
Threonine Phosphorylation Fine-Tunes the Regulatory Activity of Histone-Like Nucleoid Structuring Protein in Salmonella Transcription
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DOI: 10.3389/fmicb.2019.01515
Abstract: Histone-like nucleoid structuring protein (H-NS) in enterobacteria plays an important role in facilitating chromosome organization and functions as a crucial transcriptional regulator for global gene regulation. Here, we presented an observation that H-NS of Salmonella… read more here.
Keywords: protein; phop phoq; transcription; phosphorylation ... See more keywords
The Role of the Two-Component System PhoP/PhoQ in Intrinsic Resistance of Yersinia enterocolitica to Polymyxin
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DOI: 10.3389/fmicb.2022.758571
Abstract: Polymyxin is the “last resort” of antibiotics. The self-induced resistance to polymyxin in Gram-negative bacteria could be mediated by lipopolysaccharide (LPS) modification, which is regulated by the two-component system, PhoP/PhoQ. Yersinia enterocolitica is a common… read more here.
Keywords: enterocolitica; phop phoq; intrinsic resistance; phoq ... See more keywords