Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2131811
Abstract: Inhalation of high concentrations of phosgene often causes pulmonary edema, which obstructs the airway and causes tissue hypoxia. There is currently no specific antidote. This study was performed to investigate the effect behind pentoxifylline (PTX)… read more here.
Keywords: phosgene induced; induced lung; pentoxifylline; lung injury ... See more keywords
NEDD4 attenuates phosgene‐induced acute lung injury through the inhibition of Notch1 activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17296
Abstract: Phosgene gas leakage can cause life‐threatening acute lung injury (ALI), which is characterized by inflammation, increased vascular permeability, pulmonary oedema and oxidative stress. Although the downregulation of neuronal precursor cell‐expressed developmentally downregulated 4 (NEDD4) is… read more here.
Keywords: lung; phosgene induced; nedd4; lung injury ... See more keywords
Comprehensive Analysis of the Profiles of Differentially Expressed mRNAs, lncRNAs, and circRNAs in Phosgene-Induced Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/6278526
Abstract: Phosgene exposure can cause acute lung injury (ALI), for which there is no currently available effective treatment. Mesenchymal stem cells (MSCs) which have been proven to have therapeutic potential and be helpful in the treatment… read more here.
Keywords: mrnas lncrnas; lncrnas circrnas; phosgene induced; acute lung ... See more keywords