Ca2+ functions as a molecular switch that controls the mutually exclusive complex formation of pyridoxal phosphatase with CIB1 or calmodulin
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13795
Abstract: Pyridoxal 5′‐phosphate (PLP) is an essential cofactor for neurotransmitter metabolism. Pyridoxal phosphatase (PDXP) deficiency in mice increases PLP and γ‐aminobutyric acid levels in the brain, yet how PDXP is regulated is unclear. Here, we identify… read more here.
Keywords: phosphatase; mutually exclusive; pdxp; pyridoxal phosphatase ... See more keywords
The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14330
Abstract: Overexpression of Saccharomyces cerevisiae protein phosphatase Ppz1 strongly impairs cell growth. Ppz1 is negatively regulated by its subunit Hal3, and Hal3 overexpression fully counteracts the toxic effects derived from high levels of the phosphatase. We show… read more here.
Keywords: phosphatase; hal3; subunit hal3; ppz1 ... See more keywords
A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13171
Abstract: Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL) is secreted and is an… read more here.
Keywords: phosphatase; inhibitor; falciparum; parasite growth ... See more keywords
Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C‐Terminal Phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000669
Abstract: Phosphoprotein phosphatase‐1 (PP1) is a key player in the regulation of phospho‐serine (pSer) and phospho‐threonine (pThr) dephosphorylation and is involved in a large fraction of cellular signaling pathways. Aberrant activity of PP1 has been linked… read more here.
Keywords: protein; towards dissecting; phosphatase; mechanism ... See more keywords
Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32555
Abstract: Background and Aims: SH2 domain–containing protein tyrosine phosphatase 2 (Shp2) is the first identified pro‐oncogenic tyrosine phosphatase that acts downstream of receptor tyrosine kinases (RTKs) to promote Ras–extracellular signal–regulated kinase signaling. However, this phosphatase was… read more here.
Keywords: inhibition; shp2; phosphatase; metastasized liver ... See more keywords
Dual‐specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27420
Abstract: The Ras/mitogen‐activated protein kinase (MAPK) pathway controls fundamental cellular processes such as proliferation, differentiation, and apoptosis. The dual‐specificity phosphatase 6 (DUSP6) regulates cytoplasmic MAPK signaling by dephosphorylating and inactivating extracellular signal‐regulated kinase (ERK1/2) MAPK. To… read more here.
Keywords: dual specificity; phosphatase; deletion; dusp6 ... See more keywords
p116Rip promotes myosin phosphatase activity in airway smooth muscle cells
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DOI: 10.1002/jcp.28949
Abstract: Myosin phosphatase‐Rho interacting protein (p116Rip) was originally found as a RhoA‐binding protein. Subsequent studies by us and others revealed that p116Rip facilitates myosin light chain phosphatase (MLCP) activity through direct and indirect manners. However, it… read more here.
Keywords: phosphatase; myosin phosphatase; smooth muscle; p116rip ... See more keywords
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-022-04173-w
Abstract: Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds… read more here.
Keywords: pstpip1 lyp; lyp phosphatase; autoinflammatory disorders; interaction ... See more keywords
Microbial resource allocation for phosphatase synthesis reflects the availability of inorganic phosphorus across various soils
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DOI: 10.1007/s10533-017-0398-6
Abstract: According to the resource allocation model for extracellular enzyme synthesis, microorganisms should preferentially allocate their resources to phosphorus (P)-acquiring enzyme synthesis when P availability is low in soils. However, the validity of this model across… read more here.
Keywords: phosphatase synthesis; resource allocation; phosphatase; synthesis ... See more keywords
Alterations in the activity of certain enzymes in the gills of a carp Labeo rohita exposed to an azo dye, Eriochrome black T: a biochemical investigation
Sign Up to like & getrecommendations! Published in 2017 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-017-0458-9
Abstract: In Labeo rohita exposed to sub-lethal concentrations of an azo dye, Eriochrome black T for 4 days, gills show considerable alterations in the activity of certain metabolic enzymes—alkaline phosphatase, acid phosphatase, carboxylesterase, lactate dehydrogenase, and succinate… read more here.
Keywords: azo dye; dehydrogenase; phosphatase; rohita exposed ... See more keywords
Exploration of Zinc(II) Complexes as Potent Inhibitors Against Protein Tyrosine Phosphatase 1B
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8265-8
Abstract: Although protein tyrosine phosphatases(PTPs) do not contain any metals, their activities can be inhibited by some metal complexes. Here we investigated the inhibition of two zinc complexes with Schiff base ligands against PTPs activity to… read more here.
Keywords: phosphatase; tyrosine phosphatase; zinc complexes; protein tyrosine ... See more keywords