Biochemical Characterization of GacI, a Bifunctional Glycosyltransferase-Phosphatase Enzyme Involved in Acarbose Biosynthesis in Streptomyces glaucescens GLA.O.
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DOI: 10.1021/acs.biochem.2c00473
Abstract: Acarbose, a pseudotetrasaccharide produced by several strains of Actinoplanes and Streptomyces, is an α-glucosidase inhibitor clinically used to control type II diabetes. Bioinformatic analysis of the biosynthetic gene clusters of acarbose in Actinoplanes sp. SE50/110… read more here.
Keywords: bifunctional glycosyltransferase; acarbose biosynthesis; streptomyces glaucescens; phosphatase enzyme ... See more keywords