Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1.
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DOI: 10.1158/0008-5472.can-19-0798
Abstract: There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four PARP inhibitors. In this issue of… read more here.
Keywords: dna repair; nuclear targeting; targeting subunit; phosphatase nuclear ... See more keywords
Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression
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DOI: 10.1158/1541-7786.mcr-17-0670
Abstract: Mitotic progression is regulated largely by reversible phosphorylation events that are mediated by mitotic kinases and phosphatases. Protein phosphatase 1 (PP1) has been shown to play a crucial role in regulation of mitotic entry, progression,… read more here.
Keywords: phosphatase nuclear; nuclear targeting; aurora kinases; mitotic progression ... See more keywords