Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0635-0
Abstract: Protein phosphatase 1 (PP1) is a key regulator of important cardiac signaling pathways. Dysregulation of PP1 has been heavily implicated in cardiac dysfunctions. Accordingly, pharmacological targeting of PP1 activity is considered for therapeutic intervention in… read more here.
Keywords: pp1 isoforms; heart; pp1; phosphatase pp1 ... See more keywords
Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.
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DOI: 10.1016/j.str.2018.12.002
Abstract: SDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich repeats adopt a banana-shaped fold that is shielded from solvent by capping domains at its extremities.… read more here.
Keywords: splicing factor; phosphatase pp1; sds22; structure ... See more keywords