Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity.
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DOI: 10.1021/jacs.2c10759
Abstract: A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially for the hyperphosphorylation of oncoproteins. The hyperphosphorylation of ASK1 at Thr838 leads to a persistently high activity… read more here.
Keywords: dephosphorylation; phosphatase recruiting; activity; protein phosphatase ... See more keywords