Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00013
Abstract: Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal… read more here.
Keywords: sodium phosphate; phosphate cotransporter; cotransporter napi2a; napi2a slc34a1 ... See more keywords
Sodium phosphate cotransporter 2a inhibitors: potential therapeutic uses
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000828
Abstract: Purpose of review Targeting sodium phosphate cotransporter 2a (Npt2a) offers a novel strategy for treating hyperphosphatemia in chronic kidney disease (CKD). Here we review recent studies on the efficacy of Npt2a inhibition, its plasma phosphate… read more here.
Keywords: bay 767; inhibition; phosphate cotransporter; sodium phosphate ... See more keywords