Suppression of glucose-6-phosphate-isomerase induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of glucose-6-phosphate-isomerase
Sign Up to like & getrecommendations! Published in 2017 at "Modern Rheumatology"
DOI: 10.1080/14397595.2016.1218598
Abstract: Abstract Objective: To investigate the effects of transgenic rice seeds expressing the altered peptide ligand (APL) of human glucose-6-phosphate-isomerase (hGPI325–339) in mice model of GPI-induced arthritis (GIA). Methods: We generated transgenic rice expressing T-cell epitope… read more here.
Keywords: rice; transgenic rice; glucose phosphate; rice seeds ... See more keywords
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency
Sign Up to like & getrecommendations! Published in 2021 at "SLAS Discovery"
DOI: 10.1177/24725552211018198
Abstract: Triose phosphate isomerase deficiency (TPI Df) is an untreatable, childhood-onset glycolytic enzymopathy. Patients typically present with frequent infections, anemia, and muscle weakness that quickly progresses with severe neuromusclar dysfunction requiring aided mobility and often respiratory… read more here.
Keywords: triose phosphate; phosphate isomerase; tpi; tpi treatments ... See more keywords
[Triose phosphate isomerase deficiency: a rare erythrocyte enzymopathy with a poor prognosis].
Sign Up to like & getrecommendations! Published in 2023 at "Annales de biologie clinique"
DOI: 10.1684/abc.2023.1789
Abstract: Triose phosphate isomerase (TPI) is a crucial enzyme for glycolysis. TPI deficiency is an autosomal recessive metabolic disease described in 1965, which remains exceptional by its rarity (less than 100 cases described worldwide), but by… read more here.
Keywords: isomerase deficiency; phosphate isomerase; triose phosphate;
Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21007
Abstract: As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth… read more here.
Keywords: cell; glucose phosphate; growth; phosphate isomerase ... See more keywords
Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents.
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DOI: 10.2174/0929867328666210913090928
Abstract: BACKGROUND Parasitic diseases caused by protozoa such as Chagas disease, leishmaniasis, malaria, African trypanosomiasis, amebiasis, trichomoniasis, and giardiasis are considered serious public health problems in developing countries. Drug-resistance among parasites justifies the search for new… read more here.
Keywords: triose phosphate; antiprotozoal agents; inhibitors antiprotozoal; tim ... See more keywords
Reduced Ribose-5-Phosphate Isomerase A-1 Expression in Specific Neurons and Time Points Promotes Longevity in Caenorhabditis elegans
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DOI: 10.3390/antiox12010124
Abstract: Deregulation of redox homeostasis is often associated with an accelerated aging process. Ribose-5-phosphate isomerase A (RPIA) mediates redox homeostasis in the pentose phosphate pathway (PPP). Our previous study demonstrated that Rpi knockdown boosts the healthspan… read more here.
Keywords: phosphate; caenorhabditis elegans; rpia knockdown; rpia ... See more keywords
Density Functional Theory Calculations and Molecular Docking Analyses of Flavonoids for Their Possible Application against the Acetylcholinesterase and Triose-Phosphate Isomerase Proteins of Rhipicephalus microplus
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083606
Abstract: Ticks and tick-borne diseases constitute a substantial hazard to the livestock industry. The rising costs and lack of availability of synthetic chemical acaricides for farmers with limited resources, tick resistance to current acaricides, and residual… read more here.
Keywords: molecular docking; triose phosphate; rhipicephalus microplus; proteins rhipicephalus ... See more keywords