A paradigm towards the antimalarial quest: in silico identification and biological evaluation of novel inhibitors targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
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DOI: 10.1080/07391102.2019.1570342
Abstract: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, catalyzing the rate-limiting step of the isoprenoid synthesis pathway in the malaria parasite, is accredited as a potential drug target. In the present study, a structure based computational approach and biological evaluation were… read more here.
Keywords: deoxy xylulose; biological evaluation; phosphate reductoisomerase; xylulose phosphate ... See more keywords