ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.014
Abstract: Cholesterol is highly enriched at the plasma membrane (PM), and lipid transfer proteins may deliver cholesterol to the PM in a nonvesicular manner. Here, through a mini-screen, we identified the oxysterol binding protein (OSBP)-related protein… read more here.
Keywords: orp2; phosphatidylinositol bisphosphate; plasma membrane; cholesterol ... See more keywords
Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.09.028
Abstract: For entry, Ebola virus (EBOV) requires the interaction of its viral glycoprotein with the cellular protein Niemann-Pick C1 (NPC1) which resides in late endosomes and lysosomes. How EBOV is trafficked and delivered to NPC1 and… read more here.
Keywords: production; ebola virus; entry ebola; phosphatidylinositol bisphosphate ... See more keywords
Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate.
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DOI: 10.1021/acs.biochem.7b00547
Abstract: Phospholipase Cβ (PLCβ) enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate to produce second messengers that regulate intracellular Ca2+, cell proliferation, and survival. Their activity is dependent upon interfacial activation that occurs upon localization to cell membranes. However, the… read more here.
Keywords: adsorption; membrane adsorption; phospholipase; phosphatidylinositol bisphosphate ... See more keywords
Structural Bases for the Involvement of Phosphatidylinositol-4,5-bisphosphate in the Internalization of the Cell-Penetrating Peptide Penetratin.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00974
Abstract: Cell-penetrating peptides cross cell membranes through various parallel internalization pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) in the internalization of Penetratin. Contributions of both inner leaflet and outer leaflet… read more here.
Keywords: cell; internalization; cell penetrating; phosphatidylinositol bisphosphate ... See more keywords
A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06744-7
Abstract: Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating… read more here.
Keywords: phagocytosis; redistribution based; phosphatidylinositol bisphosphate; redistribution ... See more keywords
Acute phosphatidylinositol 4,5 bisphosphate depletion destabilizes sarcolemmal expression of cardiac L-type Ca2+ channel CaV1.2
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221242120
Abstract: Significance The potent vasopressor angiotensin II is released acutely during blood pressure control, and chronically during heart failure as a physiological strategy to increase cardiac output. We propose a mechanism, whereby angiotensin II signaling in… read more here.
Keywords: bisphosphate depletion; acute phosphatidylinositol; cardiac; expression ... See more keywords
A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2116676
Abstract: ABSTRACT Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while viruses have developed multiple ways to evade the host autophagic degradation. However, little is known as to whether viruses can target lipids to subvert… read more here.
Keywords: autophagic degradation; degradation insect; phosphatidylinositol bisphosphate; insect vector ... See more keywords
Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis
Sign Up to like & getrecommendations! Published in 2017 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcx011
Abstract: Phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is a low-abundance phospholipid known to be associated with a wide variety of physiological functions in plants. However, the localization and dynamics of PI(3,5)P2 in plant cells remain largely unknown, partially due… read more here.
Keywords: tandem ml1n; plant; probe; phosphatidylinositol bisphosphate ... See more keywords
Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.211094
Abstract: ABSTRACT This paper describes a novel type of nuclear structure – nuclear lipid islets (NLIs). They are of 40–100 nm with a lipidic interior, and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] molecules comprise a significant part of their surface.… read more here.
Keywords: formation; transcription; phosphatidylinositol bisphosphate; pol transcription ... See more keywords
Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel–Palade body exocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000788
Abstract: Phosphatidylinositol (4,5)-bisphosphate transiently accumulates at sites of Weibel–Palade body–plasma membrane fusion and promotes agonist-evoked exocytosis of endothelial von-Willebrand factor. Weibel–Palade bodies (WPB) are specialized secretory organelles of endothelial cells that control vascular hemostasis by regulated,… read more here.
Keywords: weibel palade; exocytosis; phosphatidylinositol bisphosphate; plasma membrane ... See more keywords
Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00274
Abstract: Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated derivatives (phosphoinositides) constitute a minor fraction yet exert a wide variety of… read more here.
Keywords: diverse physiological; physiological functions; fab1 phosphatidylinositol; phosphatidylinositol bisphosphate ... See more keywords