Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200196
Abstract: Phosphatidylinositol‐3‐kinases (PI3Ks) are lipid kinases that produce 3‐phosphorylated derivatives of phosphatidylinositol upon activation by various cues. These 3‐phosphorylated lipids bind to various protein effectors to control many cellular functions. Lipid phosphatases such as phosphatase and… read more here.
Keywords: control phosphatidylinositol; phosphatidylinositol kinase; nanoscale membrane; membrane ... See more keywords
Testing considerations for phosphatidylinositol‐3‐kinase catalytic subunit alpha as an emerging biomarker in advanced breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3278
Abstract: Breast cancer is the most common cancer in women, and approximately 71% of carcinomas are hormone receptor‐positive (HR+) and human epidermal growth factor receptor 2‐not‐amplified (HER2‐negative). Pathogenesis of breast cancer is associated with dysregulation of… read more here.
Keywords: catalytic subunit; advanced breast; breast cancer; phosphatidylinositol kinase ... See more keywords
Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30909
Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.
Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
Role of Phosphatidylinositol-3 Kinase Pathway in NMDA Preconditioning: Different Mechanisms for Seizures and Hippocampal Neuronal Degeneration Induced by Quinolinic Acid
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9903-5
Abstract: N-methyl D-aspartate (NMDA) preconditioning is evoked by the administration of a subtoxic dose of NMDA and is protective against neuronal excitotoxicity. This effect may involve a diversity of targets and cell signaling cascades associated to… read more here.
Keywords: neuronal degeneration; phosphatidylinositol kinase; seizures hippocampal; induced quinolinic ... See more keywords
Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase /protein kinase B pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.104579
Abstract: OBJECTIVES To investigate the effect and mechanism of calcium on LS8 cell differentiation, especially on phosphatidylinositol 3 kinase (PI3K) /protein kinase B(AKT) pathway. MATERIALS AND METHODS Ameloblast-like LS8 cell line was used and additional 0-3.5 mmol/L… read more here.
Keywords: ls8; ls8 cells; phosphatidylinositol kinase; differentiation ... See more keywords
Schwann-Cell-Specific Deletion of Phosphatidylinositol 4-Kinase Alpha Causes Aberrant Myelination.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.019
Abstract: Active membrane remodeling during myelination relies on phospholipid synthesis and membrane polarization, both of which are known to depend on inositol phospholipids. Here, we show that sciatic nerves of mice lacking phosphatidylinositol 4-kinase alpha (PI4KA)… read more here.
Keywords: phosphatidylinositol kinase; membrane; kinase alpha; myelination ... See more keywords
MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.010
Abstract: Background In our preliminary screening, expression of miR-338-5p was found to be higher in primary colorectal cancer (CRC) with metastasis. The autophagy related gene- phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3) appeared to be targeted… read more here.
Keywords: colorectal cancer; metastasis; phosphatidylinositol kinase; pik3c3 ... See more keywords
Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111718
Abstract: Phosphatidylinositol-3 kinase (PI3K) pathway is one of the most frequently activated pathogenic signaling cascades in human malignancies. PI3K is genetically mutated or overexpressed in a wide variety of cancers including ovarian, breast, prostate, gastric, colorectal,… read more here.
Keywords: pi3k; kinase pi3k; selective pi3k; phosphatidylinositol kinase ... See more keywords
Research progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174300
Abstract: Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate… read more here.
Keywords: kinase inhibitors; progress phosphatidylinositol; kinase; phosphatidylinositol kinase ... See more keywords
Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21406
Abstract: Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation. In addition, through off-target activity, AID has a much broader effect on genomic instability by… read more here.
Keywords: expression; phosphatidylinositol kinase; genomic instability; aid ... See more keywords
Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.
Sign Up to like & getrecommendations! Published in 2020 at "Nature cell biology"
DOI: 10.1038/s41556-020-00596-4
Abstract: The canonical model of agonist-stimulated phosphatidylinositol-3-OH kinase (PI3K)-Akt signalling proposes that PI3K is activated at the plasma membrane, where receptors are activated and phosphatidylinositol-4,5-bisphosphate is concentrated. Here we show that phosphatidylinositol-3,4,5-trisphosphate generation and activated Akt… read more here.
Keywords: associated protein; microtubule; microtubule associated; kinase ... See more keywords