Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2018.02.003
Abstract: Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in… read more here.
Keywords: phosphoinositide kinase; pi4 5p2; phosphatidylinositol phosphate; phosphate kinases ... See more keywords
Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.04.028
Abstract: In mycobacteria, phosphatidylinositol (PI) acts as a common lipid anchor for key components of the cell wall, including the glycolipids phosphatidylinositol mannoside (PIM), lipomannan (LM) and lipoarabinomannan (LAM). Glycolipids in Mycobacterium tuberculosis, the causative agent… read more here.
Keywords: phosphate biosynthesis; structural functional; biosynthesis; phosphatidylinositol phosphate ... See more keywords
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01819
Abstract: Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing to their central role in regulating cell signaling pathways that are either dysfunctional or can… read more here.
Keywords: allosteric binding; phosphatidylinositol phosphate; binding mode;
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00402
Abstract: Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are important molecular players in a variety of diseases, such as cancer. Currently available PI5P4K inhibitors are reversible small molecules, which may lack selectivity and sufficient cellular on-target activity. In this… read more here.
Keywords: covalent pan; phosphatidylinositol phosphate; covalent; structure ... See more keywords
Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d0sc06219g
Abstract: Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPn metabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the… read more here.
Keywords: isotope enriched; development isotope; phosphatidylinositol phosphate; development ... See more keywords
Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00366-22
Abstract: Phosphatidylinositol lipids regulate key processes, including vesicle trafficking and cell polarity. A recent study identified novel roles for phosphatidylinositol 4-phosphate (PI4P) in the plasma membrane of the fungal pathogen Candida albicans, including polarized hyphal growth… read more here.
Keywords: phosphatidylinositol phosphate; virulence; membrane; candida albicans ... See more keywords
ORP3 phosphorylation regulates phosphatidylinositol 4-phosphate and Ca2+ dynamics at PM-ER contact sites.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.237388
Abstract: Oxysterol-binding protein (OSBP)-related proteins (ORPs) mediate non-vesicular lipid-transfer between intracellular membranes. Phosphoinositide gradients play important roles in the ability of OSBP and some ORPs to transfer cholesterol and phosphatidylserine between the ER and other organelle… read more here.
Keywords: phosphorylation regulates; phosphatidylinositol phosphate; regulates phosphatidylinositol; orp3 phosphorylation ... See more keywords
Fission yeast Opy1 is an endogenous PI(4,5)P2 sensor that binds to the phosphatidylinositol 4-phosphate 5-kinase Its3
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.247973
Abstract: ABSTRACT Phosphoinositides (PIPs) are a dynamic family of lipids that execute diverse roles in cell biology. PIP levels are regulated by numerous enzymes, but our understanding of how these enzymes are controlled in space and… read more here.
Keywords: phosphatidylinositol phosphate; kinase its3; kinase; binds phosphatidylinositol ... See more keywords
ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00502
Abstract: Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are the main enzymes involved… read more here.
Keywords: phosphatidylinositol phosphate; costimulatory; isa 2011b; pro inflammatory ... See more keywords
The phosphatidylinositol 3-phosphate effector FYVE3 regulates FYVE2-dependent autophagy in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1160162
Abstract: Phosphatidylinositol 3-phosphate (PI3P) is a signaling phospholipid that play a key role in endomembrane trafficking, specifically autophagy and endosomal trafficking. However, the mechanisms underlying the contribution of PI3P downstream effectors to plant autophagy remain unknown.… read more here.
Keywords: phosphatidylinositol phosphate; fyve2 dependent; arabidopsis thaliana; autophagy arabidopsis ... See more keywords
Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10020164
Abstract: Neuronal calcium sensors are a family of N-terminally myristoylated membrane-binding proteins possessing a different intracellular localization and thereby targeting unique signaling partner(s). Apart from the myristoyl group, the membrane attachment of these proteins may be… read more here.
Keywords: protein; phosphatidylinositol phosphate; membrane binding; neuronal calcium ... See more keywords