Neuroprotective phosphatidylserine liposomes alleviate depressive-like behavior related to stroke through neuroinflammation attenuation in the mouse hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05783-1
Abstract: OBJECTIVE To investigate the protective effect of phosphatidylserine liposomes (PSL) on post-stroke (ST) injuries such as neuroinflammation and depression in mice. METHODS Brain ischemia was induced via the right unilateral common carotid artery occlusion model.… read more here.
Keywords: psl; neuroprotective phosphatidylserine; phosphatidylserine liposomes; liposomes alleviate ... See more keywords
Intravascular cells and circulating microparticles induce procoagulant activity via phosphatidylserine exposure in heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01889-8
Abstract: Relatively little information is known about the definitive role of phosphatidylserine (PS) in the hypercoagulability of heart failure (HF). Our objectives were to assess the levels of PS exposure on microparticles (MPs) and blood cells… read more here.
Keywords: phosphatidylserine; procoagulant activity; heart failure;
Phosphatidylserine Asymmetry Promotes the Membrane Insertion of a Transmembrane Helix.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.003
Abstract: The plasma membrane (PM) contains an asymmetric distribution of lipids between the inner and outer bilayer leaflets. A lipid of special interest in eukaryotic membranes is the negatively charged phosphatidylserine (PS). In healthy cells, PS… read more here.
Keywords: insertion; phlip; membrane insertion; asymmetry ... See more keywords
Bioactive ophiopogonin release form bioglass-collagen-phosphatidylserine scaffolds to enhance bone repair in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2020.127436
Abstract: Abstract The goal of this study is to construct bone scaffolds with neuroregulatory function. The scaffolds were prepared using bioglass (BG) powder, collagen (COL) solution, phosphatidylserine (PS) and ophiopogonin loaded COL microspheres as the main… read more here.
Keywords: collagen; ophiopogonin release; bioactive ophiopogonin; bioglass ... See more keywords
Cellular Labeling of Phosphatidylserine Using Clickable Serine Probes.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00813
Abstract: Phosphatidylserine (PS) is a key lipid that plays important roles in disease-related biological processes, and therefore, the means to track PS in live cells are invaluable. Herein, we describe the metabolic labeling of PS in… read more here.
Keywords: clickable serine; cellular labeling; using clickable; labeling phosphatidylserine ... See more keywords
Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04773-8
Abstract: The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS)… read more here.
Keywords: sepsis; platelet clearance; procoagulant activity; clearance ... See more keywords
Subtypes of tumour cell-derived small extracellular vesicles having differently externalized phosphatidylserine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Extracellular Vesicles"
DOI: 10.1080/20013078.2019.1579541
Abstract: ABSTRACT Phosphatidylserine (PS) has skewed distributions in the plasma membrane and is preferentially located in the inner leaflet of normal cells. Tumour cells, however, expose PS at the outer leaflet of cell surfaces, thereby potentially… read more here.
Keywords: extracellular vesicles; tumour cell; subtypes tumour; phosphatidylserine ... See more keywords
Attenuation of endothelial phosphatidylserine exposure decreases ischemia-reperfusion induced changes in microvascular permeability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001891
Abstract: BACKGROUND Translocation of phosphatidylserine from the inner leaflet to the outer leaflet of the endothelial membrane via phospholipid scramblase-1 (PLSCR1) is an apoptotic signal responsible for the loss of endothelial barrier integrity after ischemia-reperfusion injury… read more here.
Keywords: reduction; phosphatidylserine exposure; plscr1; ischemia reperfusion ... See more keywords
Phosphatidylserine liposomes containing curcumin inhibit bone loss in osteoporotic rats: A possible synergy through a common signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14120
Abstract: The present study aimed to investigate the effect of phosphatidylserine liposomes containing curcumin (PSLs-Cur) on the development of osteoporosis induced by glucocorticoids (GCs) in the rat model. PSL-Cur, phosphatidylserine (PSL), curcumin (Cur), and alendronate (AL)… read more here.
Keywords: cur; bone; curcumin; phosphatidylserine ... See more keywords
Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in T rypanosoma brucei
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13637
Abstract: Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes. In Trypanosoma brucei, PE synthesis has been shown to occur mainly via the Kennedy pathway, one of the three… read more here.
Keywords: aminophospholipid synthesis; decarboxylase; synthase; brucei ... See more keywords
Ethanol and lysozyme immobilize phosphatidylserine on cell surface for evaluating apoptosis-like decay in activated sludge bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Applied and environmental microbiology"
DOI: 10.1128/aem.00345-20
Abstract: Accurate determination of microbial viability can be crucial in microbe-dominated biosystems. However, the identification of metabolic decay in bacterial cells can be elaborate and difficult. We sought to identify apoptosis-like bacterial processes by using Annexin-V-FITC… read more here.
Keywords: treatment; phosphatidylserine; cell; apoptosis like ... See more keywords