Flippase and scramblase for phosphatidylserine exposure.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.11.009
Abstract: In various biological processes, phosphatidylserine (PtdSer) that is normally sequestered to the inner leaflet of the plasma membrane (PM) is exposed to the cell surface. When platelets are activated, they expose PtdSer to activate the… read more here.
Keywords: flippase scramblase; phosphatidylserine exposure; scramblase phosphatidylserine; ptdser ... See more keywords
Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05478-w
Abstract: Following axon injury, a cascade of signaling events is triggered to initiate axon regeneration. However, the mechanisms regulating axon regeneration are not well understood at present. In Caenorhabditis elegans, axon regeneration utilizes many of the… read more here.
Keywords: phosphatidylserine exposure; axon regeneration; abc transporter; regeneration ... See more keywords
Attenuation of endothelial phosphatidylserine exposure decreases ischemia-reperfusion induced changes in microvascular permeability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001891
Abstract: BACKGROUND Translocation of phosphatidylserine from the inner leaflet to the outer leaflet of the endothelial membrane via phospholipid scramblase-1 (PLSCR1) is an apoptotic signal responsible for the loss of endothelial barrier integrity after ischemia-reperfusion injury… read more here.
Keywords: reduction; phosphatidylserine exposure; plscr1; ischemia reperfusion ... See more keywords
Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.15441
Abstract: Phosphatidylserine (PS) exposure increases as red cells age, and is an important signal for the removal of senescent cells from the circulation. PS exposure is elevated in red cells from sickle cell anaemia (SCA) patients… read more here.
Keywords: phosphatidylserine exposure; exposure; red cells; stress ... See more keywords
Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.309473
Abstract: Objective— Phosphatidylserine exposure mediates platelet procoagulant function and regulates platelet life span. Apoptotic, necrotic, and integrin-mediated mechanisms have been implicated as intracellular determinants of platelet phosphatidylserine exposure. Here, we investigate (1) the role of mitochondrial… read more here.
Keywords: phosphatidylserine exposure; platelet; phosphatidylserine externalization; disruption ... See more keywords