Articles with "phosphine chiral" as a keyword



Asymmetric Synthesis of α-Alkylidene-β-Lactams through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand.

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Published in 2019 at "Organic letters"

DOI: 10.1021/acs.orglett.9b00276

Abstract: A copper/prolinol-phosphine chiral catalyst enabled the one-step synthesis of chiral α-alkylidene-β-lactams. Optimization of the chiral ligand for steric and electronic properties realized the highly enantioselective coupling of nitrones and propargyl alcohol derived alkynes. The resulting… read more here.

Keywords: phosphine chiral; alkylidene; alkylidene lactams; prolinol phosphine ... See more keywords