Phosphine-Mediated Bioconjugation of the 3'-End of RNA.
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DOI: 10.1021/acs.orglett.0c02982
Abstract: Staudinger ligation is an attractive bio-orthogonal reaction that has been widely used to tag proteins, carbohydrates, and nucleic acids. Here, we explore the traceless variant of the Staudinger ligation for 3'-end modification of oligoribonucleotides. An… read more here.
Keywords: phosphine mediated; bioconjugation end; end; rna ... See more keywords
Phosphine-Mediated Sequential [2+4]/[2+3] Annulation to Construct Pyrroloquinolines.
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DOI: 10.1021/acs.orglett.1c04388
Abstract: A domino [2+4]/[2+3] sequential annulation reaction of MBH carbonates with N-unprotected indoles has been developed to provide various pyrroloquinoline derivatives in ≤94% yield and 20:1 dr. The reaction could be either mediated by stoichiometric PCy3… read more here.
Keywords: annulation construct; sequential annulation; mediated sequential; annulation ... See more keywords
Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins.
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DOI: 10.1021/acs.orglett.9b04248
Abstract: We herein report a phosphine-mediated domino process of MBH-type reaction/umpolung γ-addition through the rational integration of the privileged reactivities of alkynoate. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction… read more here.
Keywords: umpolung addition; domino; mbh type; phosphine mediated ... See more keywords
Phosphine-Mediated [3+2] Cyclization for the Synthesis of Coumarin-Based CF 3 -Containing Furanones
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DOI: 10.1055/s-0042-1751434
Abstract: A tertiary phosphine-mediated [3+2] cyclization reaction of ynones with fluorinated coumarin derivatives has been developed to give a series of coumarin-based CF3-containing furanones in moderate to good yields under mild reaction conditions. Preliminary investigation into… read more here.
Keywords: coumarin based; phosphine mediated; containing furanones; mediated cyclization ... See more keywords