Phosphine-Mediated Bioconjugation of the 3'-End of RNA.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02982
Abstract: Staudinger ligation is an attractive bio-orthogonal reaction that has been widely used to tag proteins, carbohydrates, and nucleic acids. Here, we explore the traceless variant of the Staudinger ligation for 3'-end modification of oligoribonucleotides. An… read more here.
Keywords: phosphine mediated; bioconjugation end; end; rna ... See more keywords
Phosphine-Mediated Sequential [2+4]/[2+3] Annulation to Construct Pyrroloquinolines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04388
Abstract: A domino [2+4]/[2+3] sequential annulation reaction of MBH carbonates with N-unprotected indoles has been developed to provide various pyrroloquinoline derivatives in ≤94% yield and 20:1 dr. The reaction could be either mediated by stoichiometric PCy3… read more here.
Keywords: annulation construct; sequential annulation; mediated sequential; annulation ... See more keywords
Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04248
Abstract: We herein report a phosphine-mediated domino process of MBH-type reaction/umpolung γ-addition through the rational integration of the privileged reactivities of alkynoate. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction… read more here.
Keywords: umpolung addition; domino; mbh type; phosphine mediated ... See more keywords
Photocatalytic Phosphine-Mediated H2O/D2O as Only H/D Source for Radical Transfer Hydrogenation/Deuteration of α-Aryl Imino Esters
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo00446a
Abstract: Amino acids, being crucial small molecules, are of significant importance in the organic compound library. Despite their importance, the preparation of amino acids can be further refined. In this context,... read more here.
Keywords: mediated h2o; h2o d2o; source radical; photocatalytic phosphine ... See more keywords
Phosphine-Mediated [3+2] Cyclization for the Synthesis of Coumarin-Based CF 3 -Containing Furanones
Sign Up to like & getrecommendations! Published in 2022 at "Synlett"
DOI: 10.1055/s-0042-1751434
Abstract: A tertiary phosphine-mediated [3+2] cyclization reaction of ynones with fluorinated coumarin derivatives has been developed to give a series of coumarin-based CF3-containing furanones in moderate to good yields under mild reaction conditions. Preliminary investigation into… read more here.
Keywords: coumarin based; phosphine mediated; containing furanones; mediated cyclization ... See more keywords