Asymmetric addition of an N-methyl C(sp3)-H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst.
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DOI: 10.1039/d2cc04642c
Abstract: Iridium-catalyzed asymmetric C-H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give… read more here.
Keywords: phosphine olefin; addition; asymmetric addition; addition methyl ... See more keywords