Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti‐HpTGEKP Antibody and Zinc Finger Protein Linker Phospho‐Hexapeptides
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200390
Abstract: Accurate formation of antibody‐antigen complexes has been relied on in both, multitudes of scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically determined dissociation behavior of immune complexes with the anti‐HpTGEKP antibody revealed that… read more here.
Keywords: immune complexes; linker; phospho; zinc finger ... See more keywords
Anlotinib improves bile duct ligature‐induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2/mTOR pathway
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DOI: 10.1002/ddr.22019
Abstract: Cholestasis is a main clinical feature of biliary atresia (BA), which leads to liver fibrosis (LF). The focus of BA treatment is preventing and slowing the progress of LF. This study reports the improvement effect… read more here.
Keywords: anlotinib; expression; effect anlotinib; phospho ... See more keywords
Modeling, Synthesis and Characterization of Phospho–Penta–Peptide derived from PKA RII Sub Unit: A Candidate Substrate for CaN Assay
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9770-1
Abstract: Calcineurin (CaN) plays an important role in many pathological conditions like cancer, metabolic aberrations and neurodegenerative disorders. Till date contemporary methods to assay CaN uses p-nitrophenylphosphate (p-NPP) and specific protein phosphatases 2B inhibitor or use… read more here.
Keywords: peptide; phospho penta; sub unit; candidate ... See more keywords
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow
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DOI: 10.1016/j.ebiom.2021.103251
Abstract: Background The presence of no-reflow can increase the risk of major adverse cardiac events and is widely regarded as an important sign of serious prognosis. Previous studies show that laminin receptor (LR) is closely related… read more here.
Keywords: pp1c complex; phospho; pp1c; occurrence development ... See more keywords
Non-redundant functionality of lactiplantibacillus plantarum phospho-β-glucosidases revealed by carbohydrate utilization signatures associated to pbg2 and pbg4 gene mutants.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of applied microbiology"
DOI: 10.1093/jambio/lxad077
Abstract: AIM To increase our knowledge on the functionality of 6-phospho-β-glucosidases linked to phosphoenolpyruvate-dependent phosphotransferase systems (PTS) that are encountered in high redundancy in the Lactiplantibacillus plantarum WCFS1 genome. METHODS AND RESULTS Two L. plantarum WCFS1… read more here.
Keywords: capacity; phospho glucosidases; phospho; lactiplantibacillus plantarum ... See more keywords
Corydalis decumbens Can Exert Analgesic Effects in a Mouse Neuropathic Pain Model by Modulating MAPK Signaling
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DOI: 10.1155/2022/7722951
Abstract: Objectives This study is aimed at investigating the analgesic effect of the administration of Corydalis decumbens (CD) in a mouse model of postherpetic neuralgia (PHN) and at elucidating its mechanism of analgesic action. Methods Adult… read more here.
Keywords: neuropathic pain; corydalis decumbens; model; phospho ... See more keywords
Abstract 3686: RAIDs: Future prospects for innovative targeted treatments in cervical cancer
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DOI: 10.1158/1538-7445.am2018-3686
Abstract: Routine molecular diagnostic tests have yet to be introduced to guide personalized cervical cancer treatment in contrast to other solid cancers. To assess cancer functional events (CFEs), the RAIDs consortium (Rational Molecular Assessment and Innovative… read more here.
Keywords: raids future; future prospects; cervical cancer; phospho ... See more keywords
A Mild Methylation of Whole Leaf Producing Per-O-methyl Cellulo Di-phospho Amino Acid (Dipeptide)
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DOI: 10.11648/j.plant.20200801.12
Abstract: A mild methylation method is detailed in this work. It uses 1N NaOH to deprotonate primary and secondary hydroxyl groups for short time. Excess 1N NH4OH (1.00 ml, pH 11.4) is added, followed by NaHCO3… read more here.
Keywords: mild methylation; leaf; phospho; reaction conditions ... See more keywords
SAT-173 Antiproliferative Effect of Teneligliptin on Atherosclerosis in Vascular Smooth Muscle Cell
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DOI: 10.1210/js.2019-sat-173
Abstract: Abstract Background and aims: In vivo and in vitro studies revealed that sitagliptin, linagliptin treatment suppressed proliferation of vascular smooth muscle cells (VSMCs). However, data are lacking regarding the effects of teneligliptin. Here, we demonstrate… read more here.
Keywords: vascular smooth; phospho; teneligliptin; smooth muscle ... See more keywords
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
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DOI: 10.1242/bio.055012
Abstract: ABSTRACT Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role… read more here.
Keywords: apoptosis; phospho; smad3; pka ... See more keywords
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
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DOI: 10.15252/msb.20178129
Abstract: A key function of reversible protein phosphorylation is to regulate protein–protein interactions, many of which involve short linear motifs (3–12 amino acids). Motif‐based interactions are difficult to capture because of their often low‐to‐moderate affinities. Here,… read more here.
Keywords: motif based; phospho; domain interactions; phosphorylation ... See more keywords