Alzheimer’s senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1718-7
Abstract: Extracellular accumulation of Aβ peptides and intracellular aggregation of hyperphosphorylated tau proteins are the two hallmark lesions of Alzheimer disease (AD). The senile plaque is made of a core of extracellular Aβ surrounded by phospho-tau… read more here.
Keywords: technique; tissue; senile plaque; plaque ... See more keywords
High specificity of widely used phospho‐tau antibodies validated using a quantitative whole‐cell based assay
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14830
Abstract: Antibodies raised against defined phosphorylation sites of the microtubule‐associated protein tau are widely used in scientific research and being applied in clinical assays. However, recent studies have revealed an alarming degree of non‐specific binding found… read more here.
Keywords: tau; tau antibodies; widely used; phospho tau ... See more keywords
Administration of Kainic Acid Differentially Alters Astrocyte Markers and Transiently Enhanced Phospho-tau Level in Adult Rat Hippocampus
Sign Up to like & getrecommendations! Published in 2023 at "Neuroscience"
DOI: 10.2139/ssrn.4180281
Abstract: Kainic acid (KA), an analogue of the excitatory neurotransmitter glutamate, when administered systemically can trigger seizures and neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (mTLE), which affects… read more here.
Keywords: phospho tau; kainic acid; tau; rat ... See more keywords
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00421
Abstract: Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known… read more here.
Keywords: tau; tau pathology; phospho tau; pathology ... See more keywords
Plasma Phospho-Tau-181 as a Diagnostic Aid in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081879
Abstract: Cerebrospinal fluid (CSF) biomarkers remain the gold standard for fluid-biomarker-based diagnosis of Alzheimer’s disease (AD) during life. Plasma biomarkers avoid lumbar puncture and allow repeated sampling. Changes of plasma phospho-tau-181 in AD are of comparable… read more here.
Keywords: phospho tau; alzheimer disease; tau 181; phospho ... See more keywords
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021487
Abstract: Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two… read more here.
Keywords: phospho tau; monoterpenoid indole; indole alkaloids; production ... See more keywords