Structure-Guided Engineering of Human 3'-Phosphoadenosine-5'-phosphosulfate Synthetase 1 to Enhance Biosynthesis of PAPS.
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DOI: 10.1021/acs.jafc.5c07712
Abstract: 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) is the essential sulfate donor for sulfation modifications in crucial biomolecules. Human bifunctional 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (hPAPSS1) directly synthesizes PAPS in two sequential steps, circumventing the inefficiencies of multienzyme systems. However, unsatisfactory… read more here.
Keywords: phosphoadenosine phosphosulfate; phosphoadenosine; structure guided; enhance ... See more keywords