Hemodynamic, Hormonal, and Renal Actions of Phosphodiesterase-9 Inhibition in Experimental Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.05.067
Abstract: BACKGROUND Phosphodiesterase-9 (PDE9) reduces natriuretic peptide (NP) signaling and may be involved in the pathophysiology of heart failure (HF). OBJECTIVES This study investigated for the first time the integrated hemodynamic, endocrine, and renal effects of… read more here.
Keywords: normal 001; phosphodiesterase inhibition; inhibition; heart failure ... See more keywords
Phosphodiesterase-4 Inhibition in Psoriasis
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DOI: 10.2147/ptt.s303634
Abstract: Abstract Psoriasis is a chronic immune-mediated inflammatory disorder. Phosphodiesterase-4 (PDE-4) is an enzyme that mediates inflammatory responses and plays a role in psoriasis pathogenesis. PDE-4 degrades its substrate cyclic adenosine monophosphate (cAMP) to adenosine monophosphate… read more here.
Keywords: pde; pde inhibitor; psoriasis; inhibition psoriasis ... See more keywords
Pulmonary Vasculature Responsiveness to Phosphodiesterase-5A Inhibition in Heart Failure With Reduced Ejection Fraction: Possible Role of Plasma Potassium
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DOI: 10.3389/fcvm.2022.883911
Abstract: Introduction Phosphodiesterase-5a inhibition (PDE5i) leads to favorable changes in pulmonary hemodynamic and cardiac output (CO) in patients with advanced heart failure (HF) and reduced ejection fraction (HFrEF). The hemodynamic response to PDE5i could be heterogeneous… read more here.
Keywords: heart failure; potassium; plasma potassium; phosphodiesterase inhibition ... See more keywords
Clinical Implication of Phosphodiesterase-4-Inhibition
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DOI: 10.3390/ijms23031209
Abstract: The pleiotropic function of 3′,5′-cyclic adenosine monophosphate (cAMP)-dependent pathways in health and disease led to the development of pharmacological phosphodiesterase inhibitors (PDE-I) to attenuate cAMP degradation. While there are many isotypes of PDE, a predominant… read more here.
Keywords: clinical implication; implication phosphodiesterase; phosphodiesterase; phosphodiesterase inhibition ... See more keywords