Delphi consensus recommendation for optimization of pulmonary hypertension therapy focusing on switching from a phosphodiesterase 5 inhibitor to riociguat
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12055
Abstract: Abstract Dual combination therapy with a phosphodiesterase‐5 inhibitor (PDE5i) and endothelin receptor antagonist is recommended for most patients with intermediate‐risk pulmonary arterial hypertension (PAH). The RESPITE and REPLACE studies suggest that switching from a PDE5i… read more here.
Keywords: phosphodiesterase inhibitor; delphi; consensus; therapy ... See more keywords
The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101118
Abstract: Background Idiopathic pulmonary fibrosis (IPF) is a form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, with a poor prognosis. We previously showed the antifibrotic effects of a novel phosphodiesterase 4 (PDE4) inhibitor, AA6216.… read more here.
Keywords: aa6216; inhibitor aa6216; fibrosis; aa6216 suppresses ... See more keywords
Tadalafil, a Phosphodiesterase-5 Inhibitor, Improves Erectile Dysfunction in Patients With Liver Cirrhosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical and experimental hepatology"
DOI: 10.1016/j.jceh.2018.07.007
Abstract: Background Erectile dysfunction(ED) is common in patients with chronic liver disease(CLD). Although it significantly worsens the quality of life, caregivers and researchers often neglect it. Aim Evaluating the prevalence of ED in patients with CLD,… read more here.
Keywords: erectile dysfunction; score; tadalafil phosphodiesterase; etiology ... See more keywords
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00092
Abstract: The mode of action by which the orphan drug anagrelide (1), a potent cAMP phosphodiesterase 3A inhibitor, reduces blood platelet count in humans is not well understood. Recent studies indicate that 1 stabilizes a complex… read more here.
Keywords: anagrelide clinically; camp phosphodiesterase; phosphodiesterase inhibitor;
The Association of Phosphodiesterase 5 Inhibitor on Ischemia-Reperfusion Induced Kidney Injury in Rats.
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DOI: 10.22037/uj.v0i0.4173
Abstract: PURPOSE Ischemia-reperfusion (IR) causes various damage in renal tissues. The aim of the present study was to evaluate the renoprotective effect of phosphodiesterase 5 inhibitor (PDE5I) on IR induced renal injury in a rat model.… read more here.
Keywords: group; renal injury; ischemia reperfusion; injury ... See more keywords
Phosphodiesterase-5 Inhibitor Attenuates Anxious Phenotypes and Movement Disorder Induced by Mild Ischemic Stroke in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Korean Neurosurgical Society"
DOI: 10.3340/jkns.2021.0101
Abstract: Objective Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with… read more here.
Keywords: mild ischemic; induced mild; movement; phosphodiesterase inhibitor ... See more keywords
Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.883886
Abstract: Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches… read more here.
Keywords: type phosphodiesterase; cell; myeloid derived; sildenafil type ... See more keywords