Cardiovascular safety of phosphodiesterase inhibitors for treating erectile dysfunction in elderly men
Sign Up to like & getrecommendations! Published in 2017 at "Cochrane Database of Systematic Reviews"
DOI: 10.1002/14651858.cd011178.pub2
Abstract: Reason for withdrawal from publication This protocol has been withdrawn as the author team is unable to progress to the final review stage. This title is not open to a new author team as it… read more here.
Keywords: treating erectile; inhibitors treating; erectile dysfunction; cardiovascular safety ... See more keywords
Phosphodiesterase-5 inhibitors for left ventricular assist device implantation complicated by right ventricular failure.
Sign Up to like & getrecommendations! Published in 2023 at "ESC heart failure"
DOI: 10.1002/ehf2.14366
Abstract: AIMS Phosphodiesterase-5 inhibitors (PDE5I) are frequently implemented after left ventricular assist device (LVAD) implantation to improve haemodynamics in patients with early postoperative right ventricular (RV) failure. It is unknown if long-term PED5I therapy beyond the… read more here.
Keywords: ventricular assist; failure; assist device; device ... See more keywords
Reno-protective effects of Phosphodiesterase 5 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02051-6
Abstract: The kidneys are vital organs that play an important role in removing waste materials from the blood, electrolyte balance, blood pressure regulation, and red blood cell genesis. Kidney disease can be caused by various factors,… read more here.
Keywords: kidney; reno protective; phosphodiesterase inhibitors; injury ... See more keywords
Inhaled Phosphodiesterase Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease
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DOI: 10.1007/s40265-021-01616-9
Abstract: Phosphodiesterase (PDE) 4 inhibitors prevent the metabolism of cyclic adenosine monophosphate, thereby reducing inflammation. Inhaled PDE4 inhibitors aim to restrict systemic drug exposure to enhance the potential for clinical benefits (in the lungs) versus adverse… read more here.
Keywords: chronic obstructive; obstructive pulmonary; phosphodiesterase inhibitors; pulmonary disease ... See more keywords
Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2021.06.006
Abstract: OBJECTIVE Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The… read more here.
Keywords: risk; growth restriction; treatment; fetal growth ... See more keywords
Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.09.001
Abstract: Alzheimer's disease (AD), characterized by a progressive impairment of memory and cognition, is a major health problem in both developing and developed countries. Currently, no drugs can reverse the progression of AD. Phosphodiesterase 5 (PDE5)… read more here.
Keywords: pde5 inhibitors; alzheimer disease; treatment; disease ... See more keywords
Phosphodiesterase-5 Inhibitors and Outcomes During Left Ventricular Assist Device Support: A Systematic Review and Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2020.12.018
Abstract: BACKGROUND Phosphodiesterase-5 Inhibitors (PDE5i) have been used to treat pulmonary hypertension and right ventricular failure (RVF) in patients with left ventricular assist devices (LVAD). Effects of PDE5i on post-LVAD outcomes including hemocompatibility-related adverse events (HRAE)… read more here.
Keywords: post lvad; analysis; phosphodiesterase inhibitors; ventricular assist ... See more keywords
Simultaneous quantification of endothelin receptor antagonists and phosphodiesterase 5 inhibitors currently used in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.05.052
Abstract: &NA; Combination treatment with endothelin receptor antagonists (ERA) and phosphodiesterase 5 inhibitors (PDE5I) improved efficacy of pulmonary arterial hypertension (PAH) therapy. However, drug–drug interactions, variable exposure, non‐adherence can influence plasma levels. For these reasons, drug… read more here.
Keywords: drug; endothelin receptor; pulmonary arterial; receptor antagonists ... See more keywords
A Review on Phosphodiesterase-5 Inhibitors as a Topical Therapy for Erectile Dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Sexual medicine reviews"
DOI: 10.1016/j.sxmr.2022.02.002
Abstract: INTRODUCTION Due to the prevalence of erectile dysfunction and impotence among men in recent years, several pharmacotherapies have been considered for such problems. Systemic drug therapies in the treatment of erectile dysfunction have significant issues,… read more here.
Keywords: erectile dysfunction; therapy; review phosphodiesterase; phosphodiesterase inhibitors ... See more keywords
Determination of synthetic phosphodiesterase-5 inhibitors by LC-MS2 in waters and human urine submitted to dispersive liquid-liquid microextraction.
Sign Up to like & getrecommendations! Published in 2017 at "Talanta"
DOI: 10.1016/j.talanta.2017.06.076
Abstract: High-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS2) with a triple quadrupole is proposed for determining the synthetic phosphodiesterase-5 inhibitors, sildenafil, tadalafil and vardenafil, and the active metabolite N-desmethyl sildenafil. The method was successfully applied… read more here.
Keywords: human urine; liquid; dispersive liquid; synthetic phosphodiesterase ... See more keywords
Therapeutic Potential of Phosphodiesterase Inhibitors against Neurodegeneration: The Perspective of the Medicinal Chemist
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00244
Abstract: Increasing human life expectancy prompts the development of novel remedies for cognitive decline: 44 million people worldwide are affected by dementia, and this number is predicted to triple by 2050. Acetylcholinesterase and N-methyl-d-aspartate receptors represent… read more here.
Keywords: inhibitors neurodegeneration; neurodegeneration perspective; phosphodiesterase; potential phosphodiesterase ... See more keywords