Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4969
Abstract: Tumor cells may aberrantly express metabolic enzymes to adapt to their environment for survival and growth. Targeting cancer‐specific metabolic enzymes is a potential therapeutic strategy. Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate… read more here.
Keywords: growth; phosphoenolpyruvate carboxykinase; pepck; breast cancer ... See more keywords
Cytosolic phosphoenolpyruvate carboxykinase is expressed in α‐cells from human and murine pancreas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28955
Abstract: The pancreatic islets of Langerhans, mainly formed by glucagon‐producing α‐cells and insulin‐producing β‐cells, are critical for glucose homeostasis. Insulin and glucagon oppositely modulate blood glucose levels in health, but a combined decline in insulin secretion… read more here.
Keywords: glucagon secretion; glucagon; secretion; cytosolic phosphoenolpyruvate ... See more keywords
Nutritional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase at the enzymatic and molecular levels in cobia Rachycentron canadum
Sign Up to like & getrecommendations! Published in 2019 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-019-00612-x
Abstract: Despite being a carnivorous fish species, cobia (Rachycentron canadum) can utilize high levels of dietary carbohydrate (up to 360 g kg−1). By contrast, rainbow trout (also carnivorous) cannot, due to the absence of molecular induction of glycolytic… read more here.
Keywords: pyruvate kinase; cobia rachycentron; cho ratio; rachycentron canadum ... See more keywords
Asymmetric Anchoring Is Required for Efficient Ω-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase.
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DOI: 10.1021/acs.biochem.7b00178
Abstract: Mobile Ω-loops play essential roles in the function of many enzymes. Here we investigated the importance of a residue lying outside of the mobile Ω-loop element in the catalytic function of an H477R variant of… read more here.
Keywords: phosphoenolpyruvate carboxykinase; cytosolic phosphoenolpyruvate; terminus loop; loop ... See more keywords
Cytosolic phosphoenolpyruvate carboxykinase is a response gene involved in porcine adipocyte adaptation to heat stress.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of animal science"
DOI: 10.1093/jas/sky126
Abstract: Heat stress (HS) leads to increased lipid storage and expression of cytosolic phosphoenolpyruvate carboxykinase (PCK1) in pig adipocytes. However, the importance of PCK1 activation and lipid storage in the adaptive response to HS is unknown.… read more here.
Keywords: cytosolic phosphoenolpyruvate; response; heat stress; pck1 ... See more keywords
Intricate Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Isoforms in Normal Physiology and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current molecular medicine"
DOI: 10.2174/1566524019666190404155801
Abstract: BACKGROUND The phosphoenolpyruvate carboxykinase (PEPCK) isoforms are considered as rate limiting enzymes for gluconeogenesis and glyceroneogenesis pathways. PEPCK exhibits several interesting features such as a) organelle-specific isoforms (cytosolic and a mitochondrial) in vertebrate clade, b)… read more here.
Keywords: pepck isoforms; phosphoenolpyruvate carboxykinase; physiology; carboxykinase pepck ... See more keywords