Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.08.002
Abstract: Although much is known about the biochemical regulation of glycolytic enzymes, less is understood about how they are organized inside cells. We systematically examine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans.… read more here.
Keywords: subcellular compartments; pfk condensates; phosphofructokinase; pfk ... See more keywords
Structural basis for allosteric regulation of human phosphofructokinase-1
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DOI: 10.1038/s41467-024-51808-6
Abstract: Phosphofructokinase-1 (PFK1) catalyzes the rate-limiting step of glycolysis, committing glucose to conversion into cellular energy. PFK1 is highly regulated to respond to the changing energy needs of the cell. In bacteria, the structural basis of… read more here.
Keywords: phosphofructokinase; state; structural basis; pfk1 ... See more keywords
Assessment of goat milk quality based on phosphofructokinase gene mutation and interaction between phosphofructokinase and small nutrients through molecular simulation
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Dairy Technology"
DOI: 10.1111/1471-0307.70047
Abstract: Molecular biology methods are gradually applied in the detection of goat milk quality due to the limitations of traditional ways; thus, it is necessary to develop a new method to predict the contents of goat… read more here.
Keywords: goat milk; milk quality; phosphofructokinase; milk ... See more keywords
In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis
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DOI: 10.1128/spectrum.02760-21
Abstract: Finding that ammonia-generating enzymes, such as urease, and exogenous ammonia act on phosphofructokinase activity shed new light on the regulatory mechanisms that govern glycolysis. Phosphofructokinase is the key enzyme known to exert a regulatory role… read more here.
Keywords: urea hydrolysis; glycolysis; ammonia; streptococcus thermophilus ... See more keywords
Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1129791
Abstract: Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals. Cultured… read more here.
Keywords: increase; bloodstream form; form; form trypanosomes ... See more keywords