Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.08.002
Abstract: Although much is known about the biochemical regulation of glycolytic enzymes, less is understood about how they are organized inside cells. We systematically examine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans.… read more here.
Keywords: subcellular compartments; pfk condensates; phosphofructokinase; pfk ... See more keywords
In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02760-21
Abstract: Finding that ammonia-generating enzymes, such as urease, and exogenous ammonia act on phosphofructokinase activity shed new light on the regulatory mechanisms that govern glycolysis. Phosphofructokinase is the key enzyme known to exert a regulatory role… read more here.
Keywords: urea hydrolysis; glycolysis; ammonia; streptococcus thermophilus ... See more keywords
Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1129791
Abstract: Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals. Cultured… read more here.
Keywords: increase; bloodstream form; form; form trypanosomes ... See more keywords